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Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study

Liver fat can be non-invasively measured by proton magnetic resonance spectroscopy ((1)H-MRS) and fibrosis estimated as stiffness using transient elastography (FibroScan). There are no longitudinal data on changes in liver fat in Europids or on predictors of liver stiffness using these methods. We d...

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Autores principales: Lallukka, Susanna, Sädevirta, Sanja, Kallio, Markus T., Luukkonen, Panu K., Zhou, You, Hakkarainen, Antti, Lundbom, Nina, Orho-Melander, Marju, Yki-Järvinen, Hannele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674024/
https://www.ncbi.nlm.nih.gov/pubmed/29109528
http://dx.doi.org/10.1038/s41598-017-14706-0
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author Lallukka, Susanna
Sädevirta, Sanja
Kallio, Markus T.
Luukkonen, Panu K.
Zhou, You
Hakkarainen, Antti
Lundbom, Nina
Orho-Melander, Marju
Yki-Järvinen, Hannele
author_facet Lallukka, Susanna
Sädevirta, Sanja
Kallio, Markus T.
Luukkonen, Panu K.
Zhou, You
Hakkarainen, Antti
Lundbom, Nina
Orho-Melander, Marju
Yki-Järvinen, Hannele
author_sort Lallukka, Susanna
collection PubMed
description Liver fat can be non-invasively measured by proton magnetic resonance spectroscopy ((1)H-MRS) and fibrosis estimated as stiffness using transient elastography (FibroScan). There are no longitudinal data on changes in liver fat in Europids or on predictors of liver stiffness using these methods. We determined liver fat ((1)H-MRS) and clinical characteristics including features of insulin resistance at baseline and after a median follow-up period of 11.3 (range 7.3–13.4) years in 97 Finnish subjects. Liver stiffness was measured at 11.3 years. Liver fat content decreased by 5% (p < 0.05) over time. Values at baseline and 11.3 years were closely interrelated (r = 0.81, p < 0.001). Baseline liver fat (OR 1.32; 95%CI: 1.15–1.50) and change in BMI (OR 1.67; 95%CI: 1.24–2.25) were independent predictors of liver fat at 11.3 years (AUROC 0.90; 95%CI: 0.83–0.96). Baseline liver fat (AUROC 0.84; 95%CI: 0.76–0.92) predicted liver fat at 11.3 years more accurately than routinely available parameters (AUROC 0.76; 95%CI: 0.65–0.86, p = 0.02). At 11.3 years, 29% of the subjects had increased liver stiffness. Baseline liver fat (OR 2.17; 95%CI: 1.05–4.46) was an independent predictor of increased liver stiffness. These data show that liver fat is more important than the associated metabolic abnormalities as the predictor of future liver fat and fibrosis.
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spelling pubmed-56740242017-11-15 Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study Lallukka, Susanna Sädevirta, Sanja Kallio, Markus T. Luukkonen, Panu K. Zhou, You Hakkarainen, Antti Lundbom, Nina Orho-Melander, Marju Yki-Järvinen, Hannele Sci Rep Article Liver fat can be non-invasively measured by proton magnetic resonance spectroscopy ((1)H-MRS) and fibrosis estimated as stiffness using transient elastography (FibroScan). There are no longitudinal data on changes in liver fat in Europids or on predictors of liver stiffness using these methods. We determined liver fat ((1)H-MRS) and clinical characteristics including features of insulin resistance at baseline and after a median follow-up period of 11.3 (range 7.3–13.4) years in 97 Finnish subjects. Liver stiffness was measured at 11.3 years. Liver fat content decreased by 5% (p < 0.05) over time. Values at baseline and 11.3 years were closely interrelated (r = 0.81, p < 0.001). Baseline liver fat (OR 1.32; 95%CI: 1.15–1.50) and change in BMI (OR 1.67; 95%CI: 1.24–2.25) were independent predictors of liver fat at 11.3 years (AUROC 0.90; 95%CI: 0.83–0.96). Baseline liver fat (AUROC 0.84; 95%CI: 0.76–0.92) predicted liver fat at 11.3 years more accurately than routinely available parameters (AUROC 0.76; 95%CI: 0.65–0.86, p = 0.02). At 11.3 years, 29% of the subjects had increased liver stiffness. Baseline liver fat (OR 2.17; 95%CI: 1.05–4.46) was an independent predictor of increased liver stiffness. These data show that liver fat is more important than the associated metabolic abnormalities as the predictor of future liver fat and fibrosis. Nature Publishing Group UK 2017-11-06 /pmc/articles/PMC5674024/ /pubmed/29109528 http://dx.doi.org/10.1038/s41598-017-14706-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lallukka, Susanna
Sädevirta, Sanja
Kallio, Markus T.
Luukkonen, Panu K.
Zhou, You
Hakkarainen, Antti
Lundbom, Nina
Orho-Melander, Marju
Yki-Järvinen, Hannele
Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
title Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
title_full Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
title_fullStr Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
title_full_unstemmed Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
title_short Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
title_sort predictors of liver fat and stiffness in non-alcoholic fatty liver disease (nafld) – an 11-year prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674024/
https://www.ncbi.nlm.nih.gov/pubmed/29109528
http://dx.doi.org/10.1038/s41598-017-14706-0
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