Elimination of a signal sequence-uncleaved form of defective HLA protein through BAG6

A portion of newly synthesized transmembrane domain proteins tend to fail to assemble correctly in the lumen of the endoplasmic reticulum, thus resulting in the production of a signal sequence-uncleaved form of the defective species. Although the efficient degradation of these mistargeted polypeptid...

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Detalles Bibliográficos
Autores principales: Yamamoto, Koki, Hayashishita, Mizuki, Minami, Setsuya, Suzuki, Kanji, Hagiwara, Takumi, Noguchi, Aya, Kawahara, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674028/
https://www.ncbi.nlm.nih.gov/pubmed/29109525
http://dx.doi.org/10.1038/s41598-017-14975-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674028/
https://www.ncbi.nlm.nih.gov/pubmed/29109525
http://dx.doi.org/10.1038/s41598-017-14975-9

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