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SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway

BACKGROUND: Although inhibition of SGK1 has been shown to delay cancer progression, the underlying mechanisms have not yet been elucidated. METHODS: We investigated the cellular responses to GSK650394 treatment and SGK1 silencing (or overexpression) in human prostate cancer (PCa) cell lines and PC3...

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Detalles Bibliográficos
Autores principales:	Liu, Weiwei, Wang, Xuchu, Liu, Zhenping, Wang, Yiyun, Yin, Binbin, Yu, Pan, Duan, Xiuzhi, Liao, Zhaoping, Chen, Yuhua, Liu, Chunhua, Li, Xiang, Dai, Yibei, Tao, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674106/ https://www.ncbi.nlm.nih.gov/pubmed/29017179 http://dx.doi.org/10.1038/bjc.2017.293

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