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Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae
AIM: Carbapenems are antibiotics reserved for treatment of severe infections. Carbapenem antimicrobial susceptibility testing profiles were determined in a population of Klebsiella pneumoniae, and their resistance assessed based on previous and current Clinical and Laboratory Standards Institute cri...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674275/ https://www.ncbi.nlm.nih.gov/pubmed/29134129 http://dx.doi.org/10.4155/fsoa-2017-0095 |
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author | Enyinnaya, Fidelis Cruz, Patricia Buttner, Mark P Cross, Chad Woodard, David R |
author_facet | Enyinnaya, Fidelis Cruz, Patricia Buttner, Mark P Cross, Chad Woodard, David R |
author_sort | Enyinnaya, Fidelis |
collection | PubMed |
description | AIM: Carbapenems are antibiotics reserved for treatment of severe infections. Carbapenem antimicrobial susceptibility testing profiles were determined in a population of Klebsiella pneumoniae, and their resistance assessed based on previous and current Clinical and Laboratory Standards Institute criteria. MATERIALS & METHODS: Isolates were examined using an automated antimicrobial susceptibility testing method, and real time polymerase chain reaction to detect the resistance (blaKPC) gene. RESULTS: The prevalence of blaKPC gene was 45/54 (83.3%). Five isolates that were susceptible under the previous criteria changed to nonsusceptible with the current standards. The overall difference in susceptibility between the standards was 8%. CONCLUSION: This study shows that the current Clinical and Laboratory Standards Institute criteria may not offer additional benefits in the fight against carbapenem-resistant Enterobacteriaceae. |
format | Online Article Text |
id | pubmed-5674275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56742752017-11-13 Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae Enyinnaya, Fidelis Cruz, Patricia Buttner, Mark P Cross, Chad Woodard, David R Future Sci OA Research Article AIM: Carbapenems are antibiotics reserved for treatment of severe infections. Carbapenem antimicrobial susceptibility testing profiles were determined in a population of Klebsiella pneumoniae, and their resistance assessed based on previous and current Clinical and Laboratory Standards Institute criteria. MATERIALS & METHODS: Isolates were examined using an automated antimicrobial susceptibility testing method, and real time polymerase chain reaction to detect the resistance (blaKPC) gene. RESULTS: The prevalence of blaKPC gene was 45/54 (83.3%). Five isolates that were susceptible under the previous criteria changed to nonsusceptible with the current standards. The overall difference in susceptibility between the standards was 8%. CONCLUSION: This study shows that the current Clinical and Laboratory Standards Institute criteria may not offer additional benefits in the fight against carbapenem-resistant Enterobacteriaceae. Future Science Ltd 2017-10-05 /pmc/articles/PMC5674275/ /pubmed/29134129 http://dx.doi.org/10.4155/fsoa-2017-0095 Text en © 2017 Patricia Cruz This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Enyinnaya, Fidelis Cruz, Patricia Buttner, Mark P Cross, Chad Woodard, David R Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae |
title | Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae
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title_full | Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae
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title_fullStr | Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae
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title_full_unstemmed | Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae
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title_short | Comparison of Clinical & Laboratory Standards Institute standards in antimicrobial susceptibility among the carbapenemase producing Enterobacteriaceae
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title_sort | comparison of clinical & laboratory standards institute standards in antimicrobial susceptibility among the carbapenemase producing enterobacteriaceae |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674275/ https://www.ncbi.nlm.nih.gov/pubmed/29134129 http://dx.doi.org/10.4155/fsoa-2017-0095 |
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