miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14

MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets. The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma...

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Detalles Bibliográficos
Autores principales: Wang, Tong, Ren, Yipeng, Liu, Ruixun, Ma, Juntao, Shi, Yueyi, Zhang, Lei, Bu, Rongfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674489/
https://www.ncbi.nlm.nih.gov/pubmed/29204446
http://dx.doi.org/10.1155/2017/7378148
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author Wang, Tong
Ren, Yipeng
Liu, Ruixun
Ma, Juntao
Shi, Yueyi
Zhang, Lei
Bu, Rongfa
author_facet Wang, Tong
Ren, Yipeng
Liu, Ruixun
Ma, Juntao
Shi, Yueyi
Zhang, Lei
Bu, Rongfa
author_sort Wang, Tong
collection PubMed
description MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets. The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma (OSCC) remains unclear. Here we find that miR-195-5p expression is lower in OSCC than in nontumor tissues, while its overexpression in cell lines can lead to the promotion of apoptosis and the reduction of cell growth, migration, and invasion. Moreover, we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in OSCC is dependent on the interaction with TRIM14.
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spelling pubmed-56744892017-12-04 miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14 Wang, Tong Ren, Yipeng Liu, Ruixun Ma, Juntao Shi, Yueyi Zhang, Lei Bu, Rongfa Biomed Res Int Research Article MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets. The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma (OSCC) remains unclear. Here we find that miR-195-5p expression is lower in OSCC than in nontumor tissues, while its overexpression in cell lines can lead to the promotion of apoptosis and the reduction of cell growth, migration, and invasion. Moreover, we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in OSCC is dependent on the interaction with TRIM14. Hindawi 2017 2017-10-24 /pmc/articles/PMC5674489/ /pubmed/29204446 http://dx.doi.org/10.1155/2017/7378148 Text en Copyright © 2017 Tong Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Tong
Ren, Yipeng
Liu, Ruixun
Ma, Juntao
Shi, Yueyi
Zhang, Lei
Bu, Rongfa
miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
title miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
title_full miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
title_fullStr miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
title_full_unstemmed miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
title_short miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
title_sort mir-195-5p suppresses the proliferation, migration, and invasion of oral squamous cell carcinoma by targeting trim14
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674489/
https://www.ncbi.nlm.nih.gov/pubmed/29204446
http://dx.doi.org/10.1155/2017/7378148
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