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Increase of enzyme activity through specific covalent modification with fragments
Modulation of enzyme activity is a powerful means of probing cellular function and can be exploited for diverse applications. Here, we explore a method of enzyme activation where covalent tethering of a small molecule to an enzyme can increase catalytic activity (k (cat)/K (M)) up to 35-fold. Using...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674511/ https://www.ncbi.nlm.nih.gov/pubmed/29163914 http://dx.doi.org/10.1039/c7sc01966a |