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Alzheimer's disease: An alternative approach
Alzheimer's disease (AD) is the most common neurodegenerative cortical dementia. It starts with memory loss, spatial disorientation in people above the age of 65 yr with a preference to females. Its incidence is expected to increase threefold by 2050. It affects almost one out of ten persons ab...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674541/ https://www.ncbi.nlm.nih.gov/pubmed/29067973 http://dx.doi.org/10.4103/ijmr.IJMR_74_17 |
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author | Chandra, Sadanandavalli Retnaswami |
author_facet | Chandra, Sadanandavalli Retnaswami |
author_sort | Chandra, Sadanandavalli Retnaswami |
collection | PubMed |
description | Alzheimer's disease (AD) is the most common neurodegenerative cortical dementia. It starts with memory loss, spatial disorientation in people above the age of 65 yr with a preference to females. Its incidence is expected to increase threefold by 2050. It affects almost one out of ten persons above the age of 65 years. Majority of patients are sporadic, but a very small percentage is autosomal dominant. The pathomechanisms postulated include amyloid cascade hypothesis according to which mutation in amyloid precursor protein causes Aβ aggregation. The next hypothesis is signal transducer and activation of transcription 3 (STAT3) causing aberration in intracellular signalling pathways. Senile plaques and neurofibrillary tangles are other important pathological changes reported. It is observed that dementia research has not yielded the expected result world over, and therefore, the pitfalls with reference to known facts about diagnosis, clinical features, pathogenic mechanisms, assessment of progression, biomarkers, treatment and prevention, as well as brief information on our experiments with relatively inexpensive methods of differentiating the most common types of dementia AD and frontotemporal dementia are discussed. |
format | Online Article Text |
id | pubmed-5674541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56745412017-11-17 Alzheimer's disease: An alternative approach Chandra, Sadanandavalli Retnaswami Indian J Med Res Review Article Alzheimer's disease (AD) is the most common neurodegenerative cortical dementia. It starts with memory loss, spatial disorientation in people above the age of 65 yr with a preference to females. Its incidence is expected to increase threefold by 2050. It affects almost one out of ten persons above the age of 65 years. Majority of patients are sporadic, but a very small percentage is autosomal dominant. The pathomechanisms postulated include amyloid cascade hypothesis according to which mutation in amyloid precursor protein causes Aβ aggregation. The next hypothesis is signal transducer and activation of transcription 3 (STAT3) causing aberration in intracellular signalling pathways. Senile plaques and neurofibrillary tangles are other important pathological changes reported. It is observed that dementia research has not yielded the expected result world over, and therefore, the pitfalls with reference to known facts about diagnosis, clinical features, pathogenic mechanisms, assessment of progression, biomarkers, treatment and prevention, as well as brief information on our experiments with relatively inexpensive methods of differentiating the most common types of dementia AD and frontotemporal dementia are discussed. Medknow Publications & Media Pvt Ltd 2017-06 /pmc/articles/PMC5674541/ /pubmed/29067973 http://dx.doi.org/10.4103/ijmr.IJMR_74_17 Text en Copyright: © 2017 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Chandra, Sadanandavalli Retnaswami Alzheimer's disease: An alternative approach |
title | Alzheimer's disease: An alternative approach |
title_full | Alzheimer's disease: An alternative approach |
title_fullStr | Alzheimer's disease: An alternative approach |
title_full_unstemmed | Alzheimer's disease: An alternative approach |
title_short | Alzheimer's disease: An alternative approach |
title_sort | alzheimer's disease: an alternative approach |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674541/ https://www.ncbi.nlm.nih.gov/pubmed/29067973 http://dx.doi.org/10.4103/ijmr.IJMR_74_17 |
work_keys_str_mv | AT chandrasadanandavalliretnaswami alzheimersdiseaseanalternativeapproach |