Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years

Vibrio cholerae is responsible for the cause of severe life-threatening infection known as cholera. The study aimed to analyze the genetic make-up of V. cholerae O139 isolates from India and compare its phylogeny with the global strains. The genome data revealed that all isolates were of same sequen...

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Autores principales: Anandan, Shalini, Devanga Ragupathi, Naveen Kumar, Muthuirulandi Sethuvel, Dhiviya Prabaa, Thangamani, Suji, Veeraraghavan, Balaji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Genome Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674738/
https://www.ncbi.nlm.nih.gov/pubmed/29142593
http://dx.doi.org/10.1186/s13099-017-0210-0
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author Anandan, Shalini
Devanga Ragupathi, Naveen Kumar
Muthuirulandi Sethuvel, Dhiviya Prabaa
Thangamani, Suji
Veeraraghavan, Balaji
author_facet Anandan, Shalini
Devanga Ragupathi, Naveen Kumar
Muthuirulandi Sethuvel, Dhiviya Prabaa
Thangamani, Suji
Veeraraghavan, Balaji
author_sort Anandan, Shalini
collection PubMed
description Vibrio cholerae is responsible for the cause of severe life-threatening infection known as cholera. The study aimed to analyze the genetic make-up of V. cholerae O139 isolates from India and compare its phylogeny with the global strains. The genome data revealed that all isolates were of same sequence type (ST69) which belongs to seventh pandemic clone, with same virulence gene profile and, antimicrobial resistance gene profile except for two isolates. No known CRISPR repeats were identified in any of these isolates. Three different phages were identified among the isolates. All the isolates were found to harbour int (SXT) and seventh pandemic-specific gene (VC2346). Results from this study enhance our understanding on the persistence of ST69 V. cholerae O139 over 20 years.
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spelling pubmed-56747382017-11-15 Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years Anandan, Shalini Devanga Ragupathi, Naveen Kumar Muthuirulandi Sethuvel, Dhiviya Prabaa Thangamani, Suji Veeraraghavan, Balaji Gut Pathog Genome Report Vibrio cholerae is responsible for the cause of severe life-threatening infection known as cholera. The study aimed to analyze the genetic make-up of V. cholerae O139 isolates from India and compare its phylogeny with the global strains. The genome data revealed that all isolates were of same sequence type (ST69) which belongs to seventh pandemic clone, with same virulence gene profile and, antimicrobial resistance gene profile except for two isolates. No known CRISPR repeats were identified in any of these isolates. Three different phages were identified among the isolates. All the isolates were found to harbour int (SXT) and seventh pandemic-specific gene (VC2346). Results from this study enhance our understanding on the persistence of ST69 V. cholerae O139 over 20 years. BioMed Central 2017-11-06 /pmc/articles/PMC5674738/ /pubmed/29142593 http://dx.doi.org/10.1186/s13099-017-0210-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Genome Report
Anandan, Shalini
Devanga Ragupathi, Naveen Kumar
Muthuirulandi Sethuvel, Dhiviya Prabaa
Thangamani, Suji
Veeraraghavan, Balaji
Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years
title Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years
title_full Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years
title_fullStr Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years
title_full_unstemmed Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years
title_short Prevailing clone (ST69) of Vibrio cholerae O139 in India over 10 years
title_sort prevailing clone (st69) of vibrio cholerae o139 in india over 10 years
topic Genome Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674738/
https://www.ncbi.nlm.nih.gov/pubmed/29142593
http://dx.doi.org/10.1186/s13099-017-0210-0
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