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A novel intracellular pool of LFA-1 is critical for asymmetric CD8(+) T cell activation and differentiation

The integrin lymphocyte function–associated antigen 1 (LFA-1; CD11a/CD18) is a key T cell adhesion receptor that mediates stable interactions with antigen-presenting cell (APC), as well as chemokine-mediated migration. Using our newly generated CD11a-mYFP knock-in mice, we discovered that naive CD8(...

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Detalles Bibliográficos
Autores principales:	Capece, Tara, Walling, Brandon L., Lim, Kihong, Kim, Kyun-Do, Bae, Seyeon, Chung, Hung-Li, Topham, David J., Kim, Minsoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674876/ https://www.ncbi.nlm.nih.gov/pubmed/28954823 http://dx.doi.org/10.1083/jcb.201609072

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