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The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast

The size of nearly all cells is modulated by nutrients. Thus, cells growing in poor nutrients can be nearly half the size of cells in rich nutrients. In budding yeast, cell size is thought to be controlled almost entirely by a mechanism that delays cell cycle entry until sufficient growth has occurr...

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Detalles Bibliográficos
Autores principales: Leitao, Ricardo M., Kellogg, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674877/
https://www.ncbi.nlm.nih.gov/pubmed/28939614
http://dx.doi.org/10.1083/jcb.201609114
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author Leitao, Ricardo M.
Kellogg, Douglas R.
author_facet Leitao, Ricardo M.
Kellogg, Douglas R.
author_sort Leitao, Ricardo M.
collection PubMed
description The size of nearly all cells is modulated by nutrients. Thus, cells growing in poor nutrients can be nearly half the size of cells in rich nutrients. In budding yeast, cell size is thought to be controlled almost entirely by a mechanism that delays cell cycle entry until sufficient growth has occurred in G1 phase. Here, we show that most growth of a new daughter cell occurs in mitosis. When the rate of growth is slowed by poor nutrients, the duration of mitosis is increased, which suggests that cells compensate for slow growth in mitosis by increasing the duration of growth. The amount of growth required to complete mitosis is reduced in poor nutrients, leading to a large reduction in cell size. Together, these observations suggest that mechanisms that control the extent of growth in mitosis play a major role in cell size control in budding yeast.
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spelling pubmed-56748772018-05-06 The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast Leitao, Ricardo M. Kellogg, Douglas R. J Cell Biol Research Articles The size of nearly all cells is modulated by nutrients. Thus, cells growing in poor nutrients can be nearly half the size of cells in rich nutrients. In budding yeast, cell size is thought to be controlled almost entirely by a mechanism that delays cell cycle entry until sufficient growth has occurred in G1 phase. Here, we show that most growth of a new daughter cell occurs in mitosis. When the rate of growth is slowed by poor nutrients, the duration of mitosis is increased, which suggests that cells compensate for slow growth in mitosis by increasing the duration of growth. The amount of growth required to complete mitosis is reduced in poor nutrients, leading to a large reduction in cell size. Together, these observations suggest that mechanisms that control the extent of growth in mitosis play a major role in cell size control in budding yeast. The Rockefeller University Press 2017-11-06 /pmc/articles/PMC5674877/ /pubmed/28939614 http://dx.doi.org/10.1083/jcb.201609114 Text en © 2017 Leitao and Kellogg http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Leitao, Ricardo M.
Kellogg, Douglas R.
The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
title The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
title_full The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
title_fullStr The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
title_full_unstemmed The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
title_short The duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
title_sort duration of mitosis and daughter cell size are modulated by nutrients in budding yeast
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674877/
https://www.ncbi.nlm.nih.gov/pubmed/28939614
http://dx.doi.org/10.1083/jcb.201609114
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