Cargando…

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading

Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 plays a central role for cell adhesion and membrane protrusion by directly binding and recruiting paxillin to nascent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Böttcher, Ralph T., Veelders, Maik, Rombaut, Pascaline, Faix, Jan, Theodosiou, Marina, Stradal, Theresa E., Rottner, Klemens, Zent, Roy, Herzog, Franz, Fässler, Reinhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674885/ https://www.ncbi.nlm.nih.gov/pubmed/28912124 http://dx.doi.org/10.1083/jcb.201701176

Ejemplares similares

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin
por: Theodosiou, Marina, et al.
Publicado: (2016)

ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning
por: Fäßler, Florian, et al.
Publicado: (2023)

Arp2/3 complex interactions and actin network turnover in lamellipodia
por: Lai, Frank PL, et al.
Publicado: (2008)

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42
por: Block, Jennifer, et al.
Publicado: (2012)

A kindlin-3–leupaxin–paxillin signaling pathway regulates podosome stability
por: Klapproth, Sarah, et al.
Publicado: (2019)

Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation
por: Dimchev, Vanessa, et al.
Publicado: (2021)

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin
por: Koestler, Stefan A., et al.
Publicado: (2013)

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells
por: Hu, Ying-Li, et al.
Publicado: (2014)

Paxillin: A Hub for Mechano-Transduction from the β3 Integrin-Talin-Kindlin Axis
por: Ripamonti, Marta, et al.
Publicado: (2022)

Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion
por: Fischer, Lisa S., et al.
Publicado: (2021)

A mechanism of leading-edge protrusion in the absence of Arp2/3 complex
por: Suraneni, Praveen, et al.
Publicado: (2015)

Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
por: DeMali, Kris A., et al.
Publicado: (2002)

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
por: Orré, Thomas, et al.
Publicado: (2021)

Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond
por: Bodescu, Mihai Adrian, et al.
Publicado: (2023)

Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
por: Schwan, Carsten, et al.
Publicado: (2022)

Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
por: Zhan, Jun, et al.
Publicado: (2012)

WASP stings into matrix to lead immune cell migration
por: Rottner, Klemens, et al.
Publicado: (2022)

CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
por: Chen, Nan-Peng, et al.
Publicado: (2022)

The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts
por: Papalazarou, Vassilis, et al.
Publicado: (2020)

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous epithelial stem cell proliferation
por: Rognoni, Emanuel, et al.
Publicado: (2014)

Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly
por: Dimchev, Georgi, et al.
Publicado: (2017)

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction
por: Ussar, Siegfried, et al.
Publicado: (2008)

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus
por: Moretti, Federico Andrea, et al.
Publicado: (2018)

Paxillin phosphorylation at Ser273 localizes a GIT1–PIX–PAK complex and regulates adhesion and protrusion dynamics
por: Nayal, Anjana, et al.
Publicado: (2006)

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption
por: Schmidt, Sarah, et al.
Publicado: (2011)

Of Kindlins and Cancer
por: Plow, Edward F., et al.
Publicado: (2016)

Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells
por: Ruppert, Raphael, et al.
Publicado: (2015)

On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility
por: Dolati, Setareh, et al.
Publicado: (2018)

Theoretical Model for Cellular Shapes Driven by Protrusive and Adhesive Forces
por: Kabaso, Doron, et al.
Publicado: (2011)

GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation
por: Rohena, Cristina, et al.
Publicado: (2020)

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)
por: West, Kip A., et al.
Publicado: (2001)

Knockdown of the KINDLIN-2 Gene and Reduced Expression of Kindlin-2 Affects Vascular Permeability in Angiogenesis in a Mouse Model of Wound Healing
por: Ying, Jianghui, et al.
Publicado: (2018)

Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function
por: Martin, Adam C., et al.
Publicado: (2005)

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
por: Steffen, Anika, et al.
Publicado: (2013)

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
por: Kage, Frieda, et al.
Publicado: (2017)

Kindlin-2 is required for myocyte elongation and is essential for myogenesis
por: Dowling, James J, et al.
Publicado: (2008)

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts
por: Godbout, Elena, et al.
Publicado: (2020)

Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
por: Kage, Frieda, et al.
Publicado: (2019)

Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_05ki98ga11u4phcog0419me2pg