Cargando…
Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly
Synapse assembly likely requires postsynaptic target recognition by incoming presynaptic afferents. Using newly generated conditional knock-in and knockout mice, we show in this study that latrophilin-2 (Lphn2), a cell-adhesion G protein–coupled receptor and presumptive α-latrotoxin receptor, contro...
Autores principales: | Anderson, Garret R., Maxeiner, Stephan, Sando, Richard, Tsetsenis, Theodoros, Malenka, Robert C., Südhof, Thomas C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674891/ https://www.ncbi.nlm.nih.gov/pubmed/28972101 http://dx.doi.org/10.1083/jcb.201703042 |
Ejemplares similares
-
Latrophilin GPCR signaling mediates synapse formation
por: Sando, Richard, et al.
Publicado: (2021) -
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum
por: Zhang, Roger Shen, et al.
Publicado: (2020) -
Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism
por: Li, Jingxian, et al.
Publicado: (2020) -
A Comprehensive Mutagenesis Screen of the Adhesion GPCR Latrophilin-1/ADGRL1
por: Nazarko, Olha, et al.
Publicado: (2018) -
Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
por: Kordon, Szymon P., et al.
Publicado: (2023)