Retromer revisited: Evolving roles for retromer in endosomal sorting

The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703015) fundamenta...

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Detalles Bibliográficos
Autores principales: Chamberland, John P., Ritter, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674901/
https://www.ncbi.nlm.nih.gov/pubmed/29061649
http://dx.doi.org/10.1083/jcb.201708111
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author Chamberland, John P.
Ritter, Brigitte
author_facet Chamberland, John P.
Ritter, Brigitte
author_sort Chamberland, John P.
collection PubMed
description The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703015) fundamentally question the current retromer model and demonstrate that in mammalian cells, the individual retromer subcomplexes have functionally diverged to organize multiple distinct sorting pathways.
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spelling pubmed-56749012018-05-06 Retromer revisited: Evolving roles for retromer in endosomal sorting Chamberland, John P. Ritter, Brigitte J Cell Biol Commentary The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703015) fundamentally question the current retromer model and demonstrate that in mammalian cells, the individual retromer subcomplexes have functionally diverged to organize multiple distinct sorting pathways. The Rockefeller University Press 2017-11-06 /pmc/articles/PMC5674901/ /pubmed/29061649 http://dx.doi.org/10.1083/jcb.201708111 Text en © 2017 Chamberland and Ritter http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Chamberland, John P.
Ritter, Brigitte
Retromer revisited: Evolving roles for retromer in endosomal sorting
title Retromer revisited: Evolving roles for retromer in endosomal sorting
title_full Retromer revisited: Evolving roles for retromer in endosomal sorting
title_fullStr Retromer revisited: Evolving roles for retromer in endosomal sorting
title_full_unstemmed Retromer revisited: Evolving roles for retromer in endosomal sorting
title_short Retromer revisited: Evolving roles for retromer in endosomal sorting
title_sort retromer revisited: evolving roles for retromer in endosomal sorting
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674901/
https://www.ncbi.nlm.nih.gov/pubmed/29061649
http://dx.doi.org/10.1083/jcb.201708111
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