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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD

INTRODUCTION: We have previously established a link between impaired phagocytic capacity and deregulated S1P signaling in alveolar macrophages from COPD subjects. We hypothesize that this defect may include a disruption of epithelial-macrophage crosstalk via Spns2-mediated intercellular S1P signalin...

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Detalles Bibliográficos
Autores principales:	Tran, Hai B., Jersmann, Hubertus, Truong, Tung Thanh, Hamon, Rhys, Roscioli, Eugene, Ween, Miranda, Pitman, Melissa R., Pitson, Stuart M., Hodge, Greg, Reynolds, Paul N., Hodge, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675303/ https://www.ncbi.nlm.nih.gov/pubmed/29112690 http://dx.doi.org/10.1371/journal.pone.0179577

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