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Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway

LMB-100 (RG7787) is a recombinant immunotoxin, which kills mesothelin-expressing cancer cells and now being evaluated in phase 1 trials. To enhance the anti-tumor activity of LMB-100, we have searched for agents, already approved for cancer therapy, that can be combined with LMB-100 to increase its...

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Detalles Bibliográficos
Autores principales:	Liu, Xiu-Fen, Zhou, Qi, Hassan, Raffit, Pastan, Ira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675634/ https://www.ncbi.nlm.nih.gov/pubmed/29152082 http://dx.doi.org/10.18632/oncotarget.20263

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