Disrupting glucose-6-phosphate isomerase fully suppresses the “Warburg effect” and activates OXPHOS with minimal impact on tumor growth except in hypoxia

As Otto Warburg first observed, cancer cells largely favor fermentative glycolysis for growth even under aerobic conditions. This energy paradox also extends to rapidly growing normal cells indicating that glycolysis is optimal for fast growth and biomass production. Here we further explored this co...

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Detalles Bibliográficos
Autores principales: de Padua, Monique Cunha, Delodi, Giulia, Vučetić, Milica, Durivault, Jérôme, Vial, Valérie, Bayer, Pascale, Noleto, Guilhermina Rodrigues, Mazure, Nathalie M., Ždralević, Maša, Pouysségur, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675658/
https://www.ncbi.nlm.nih.gov/pubmed/29152106
http://dx.doi.org/10.18632/oncotarget.21007

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