Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase

Cancer cells are able to uptake extracellular ATP (eATP) via macropinocytosis to elevate intracellular ATP (iATP) levels, enhancing their survival in drug treatment. However, the involved drug resistance mechanisms are unknown. Here we investigated the roles of eATP as either an energy or a phosphor...

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Detalles Bibliográficos
Autores principales: Wang, Xuan, Li, Yunsheng, Qian, Yanrong, Cao, Yanyang, Shriwas, Pratik, Zhang, Haiyun, Chen, Xiaozhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675678/
https://www.ncbi.nlm.nih.gov/pubmed/29152126
http://dx.doi.org/10.18632/oncotarget.21231

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