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Notch1 ablation radiosensitizes glioblastoma cells

Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients. Furthermore, using the CRISPR/Cas9 system,...

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Detalles Bibliográficos
Autores principales:	Han, Na, Hu, Guangyuan, Shi, Lei, Long, Guoxian, Yang, Lin, Xi, Qingsong, Guo, Qiuyun, Wang, Jianhua, Dong, Zhen, Zhang, Mengxian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675693/ https://www.ncbi.nlm.nih.gov/pubmed/29152141 http://dx.doi.org/10.18632/oncotarget.21409

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