Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma

Self-renewing tumor-initiating cells (TICs) are thought to be responsible for tumor recurrence and chemo-resistance. Glycine decarboxylase, encoded by the GLDC gene, is reported to be overexpressed in TIC-enriched primary non-small-cell lung carcinoma (NSCLC). GLDC is a component of the mitochondria...

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Detalles Bibliográficos
Autores principales: Lin, Jing, Lee, Jia Hui Jane, Paramasivam, Kathirvel, Pathak, Elina, Wang, Zhenxun, Pramono, Zacharias Aloysius Dwi, Lim, Bing, Wee, Keng Boon, Surana, Uttam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675722/
https://www.ncbi.nlm.nih.gov/pubmed/29246305
http://dx.doi.org/10.1016/j.omtn.2017.10.001

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