Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation

Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context...

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Detalles Bibliográficos
Autores principales: Zumerle, Sara, Molon, Barbara, Viola, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675840/
https://www.ncbi.nlm.nih.gov/pubmed/29163534
http://dx.doi.org/10.3389/fimmu.2017.01467
Descripción
Sumario:Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context in which the antigen is presented. In this review, we discuss of membrane rafts in the context of T cell signaling, focusing on CD28-mediated costimulation.

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