Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation

Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context...

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Detalles Bibliográficos
Autores principales: Zumerle, Sara, Molon, Barbara, Viola, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675840/
https://www.ncbi.nlm.nih.gov/pubmed/29163534
http://dx.doi.org/10.3389/fimmu.2017.01467
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author Zumerle, Sara
Molon, Barbara
Viola, Antonella
author_facet Zumerle, Sara
Molon, Barbara
Viola, Antonella
author_sort Zumerle, Sara
collection PubMed
description Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context in which the antigen is presented. In this review, we discuss of membrane rafts in the context of T cell signaling, focusing on CD28-mediated costimulation.
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spelling pubmed-56758402017-11-21 Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation Zumerle, Sara Molon, Barbara Viola, Antonella Front Immunol Immunology Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context in which the antigen is presented. In this review, we discuss of membrane rafts in the context of T cell signaling, focusing on CD28-mediated costimulation. Frontiers Media S.A. 2017-11-03 /pmc/articles/PMC5675840/ /pubmed/29163534 http://dx.doi.org/10.3389/fimmu.2017.01467 Text en Copyright © 2017 Zumerle, Molon and Viola. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zumerle, Sara
Molon, Barbara
Viola, Antonella
Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
title Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
title_full Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
title_fullStr Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
title_full_unstemmed Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
title_short Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
title_sort membrane rafts in t cell activation: a spotlight on cd28 costimulation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675840/
https://www.ncbi.nlm.nih.gov/pubmed/29163534
http://dx.doi.org/10.3389/fimmu.2017.01467
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AT molonbarbara membraneraftsintcellactivationaspotlightoncd28costimulation
AT violaantonella membraneraftsintcellactivationaspotlightoncd28costimulation

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