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An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Efficient and safe induction of CD8(+) T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens of interest. In particular, the selection of suc...

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Detalles Bibliográficos
Autores principales:	Platteel, Anouk C. M., Liepe, Juliane, van Eden, Willem, Mishto, Michele, Sijts, Alice J. A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675849/ https://www.ncbi.nlm.nih.gov/pubmed/29163514 http://dx.doi.org/10.3389/fimmu.2017.01441

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