Cargando…

Isoniazid-induced Pure Red Cell Aplasia in a Patient with Sarcoidosis: A Patient Summary and Review of the Literature

A 41-year-old woman treated with isoniazid (INH) for latent tuberculosis infection and an oral corticosteroid for sarcoidosis developed severe anemia two months after initiating INH. A bone marrow examination showed erythroblastopenia, and a diagnosis of INH-induced pure red cell aplasia (PRCA) was...

Descripción completa

Detalles Bibliográficos
Autores principales: Saito, Yasuyuki, Sawada, Yuri, Koga, Yasuhiko, Sunaga, Noriaki, Tsukagoshi, Yusuke, Hachisu, Yoshimasa, Osaki, Takashi, Sakurai, Reiko, Kaira, Kyoichi, Ono, Akihiro, Sato, Ken, Koiso, Hiromi, Oyama, Tetsunari, Hisada, Takeshi, Yamada, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675938/
https://www.ncbi.nlm.nih.gov/pubmed/28924112
http://dx.doi.org/10.2169/internalmedicine.8379-16
Descripción
Sumario:A 41-year-old woman treated with isoniazid (INH) for latent tuberculosis infection and an oral corticosteroid for sarcoidosis developed severe anemia two months after initiating INH. A bone marrow examination showed erythroblastopenia, and a diagnosis of INH-induced pure red cell aplasia (PRCA) was made. Her reticulocyte count and hemoglobin levels improved two weeks after discontinuation of INH. A literature review of INH-induced PRCA shows that it occurs very rarely in the context of autoimmune disorders. This report describes a case of INH-induced PRCA occurring in a patient with sarcoidosis.