Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice

Recombinant adeno-associated virus (rAAV)-mediated gene delivery shows promise to transduce the pancreas, but safety/efficacy in a neoplastic context is not well established. To identify an ideal AAV serotype, route, and vector dose and assess safety, we have investigated the use of three AAV seroty...

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Detalles Bibliográficos
Autores principales: Quirin, Kayla A., Kwon, Jason J., Alioufi, Arafat, Factora, Tricia, Temm, Constance J., Jacobsen, Max, Sandusky, George E., Shontz, Kim, Chicoine, Louis G., Clark, K. Reed, Mendell, Joshua T., Korc, Murray, Kota, Janaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675991/
https://www.ncbi.nlm.nih.gov/pubmed/29349096
http://dx.doi.org/10.1016/j.omtm.2017.09.006

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