Cargando…

In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles

Obesity, metabolic syndrome, and hyperleptinemia are associated with aging and age‐associated diseases including prostate cancer. One experimental approach to inhibit tumor growth is to reduce dietary protein intake and hence levels of circulating amino acids. Dietary protein restriction (PR) increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eitan, Erez, Tosti, Valeria, Suire, Caitlin N., Cava, Edda, Berkowitz, Sean, Bertozzi, Beatrice, Raefsky, Sophia M., Veronese, Nicola, Spangler, Ryan, Spelta, Francesco, Mustapic, Maja, Kapogiannis, Dimitrios, Mattson, Mark P., Fontana, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Short Takes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676054/ https://www.ncbi.nlm.nih.gov/pubmed/28921841 http://dx.doi.org/10.1111/acel.12657

Ejemplares similares

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
por: Fontana, Luigi, et al.
Publicado: (2018)

Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults
por: Demaria, Marco, et al.
Publicado: (2023)

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
por: Mustapic, Maja, et al.
Publicado: (2017)

Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus
por: Hamilton, Kelly A., et al.
Publicado: (2018)

Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca(2+)-handling deficits in Alzheimer’s disease models
por: Eitan, Erez, et al.
Publicado: (2016)

Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age
por: Grenier‐Pleau, Isabelle, et al.
Publicado: (2020)

Robust, universal biomarker assay to detect senescent cells in biological specimens
por: Evangelou, Konstantinos, et al.
Publicado: (2016)

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model
por: Lamming, Dudley W., et al.
Publicado: (2015)

Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model
por: Miwa, Satomi, et al.
Publicado: (2008)

The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
por: Reeve, Amy K, et al.
Publicado: (2009)

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging
por: Hackl, Matthias, et al.
Publicado: (2010)

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts
por: Nooteboom, Marco, et al.
Publicado: (2010)

The overexpression of major antioxidant enzymes does not extend the lifespan of mice
por: Pérez, Viviana I, et al.
Publicado: (2009)

Age-related variation in immunity in a wild mammal population
por: Nussey, Daniel H, et al.
Publicado: (2012)

Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs
por: Waters, David J, et al.
Publicado: (2009)

Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts
por: Saha, Bidisha, et al.
Publicado: (2014)

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
por: Milman, Sofiya, et al.
Publicado: (2014)

IGF-I regulates the age-dependent signaling peptide humanin
por: Lee, Changhan, et al.
Publicado: (2014)

A genomics approach identifies senescence-specific gene expression regulation
por: Lackner, Daniel H, et al.
Publicado: (2014)

Deleted in Breast Cancer 1 regulates cellular senescence during obesity
por: Escande, Carlos, et al.
Publicado: (2014)

Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles
por: Snyder-Mackler, Noah, et al.
Publicado: (2014)

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice
por: Mercken, Evi M, et al.
Publicado: (2014)

Vitamin A deficiency: what eye health workers can do
por: Adebisi, Babajide, et al.
Publicado: (2013)

Do altered energy metabolism or spontaneous locomotion ‘mediate’ decelerated senescence?
por: Arum, Oge, et al.
Publicado: (2015)

The rejuvenating effect of pregnancy on muscle regeneration
por: Falick Michaeli, Tal, et al.
Publicado: (2015)

Paternal age and telomere length in twins: the germ stem cell selection paradigm
por: Hjelmborg, Jacob B, et al.
Publicado: (2015)

Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice
por: Mendias, Christopher L, et al.
Publicado: (2015)

The life-extending effect of dietary restriction requires Foxo3 in mice
por: Shimokawa, Isao, et al.
Publicado: (2015)

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2015)

Age‐related changes in murine myometrial transcript profile are mediated by exposure to the female sex hormones
por: Chong, Hsu P., et al.
Publicado: (2015)

Intact endothelial autophagy is required to maintain vascular lipid homeostasis
por: Torisu, Kumiko, et al.
Publicado: (2015)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna (Dhe) mice
por: Xin, Lijun, et al.
Publicado: (2015)

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response
por: Valapala, Mallika, et al.
Publicado: (2014)

Immunochip analysis identifies association of the RAD50/IL13 region with human longevity
por: Flachsbart, Friederike, et al.
Publicado: (2016)

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
por: Hinken, Aaron C., et al.
Publicado: (2016)

CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
por: Spyridopoulos, Ioakim, et al.
Publicado: (2015)

Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway
por: Zhang, Dan, et al.
Publicado: (2015)

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human
por: MacRae, Sheila L, et al.
Publicado: (2015)

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress
por: Page, Melissa M, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pt4acdb6be5f960m5lh2nuv0e7