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Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes
Obesity and metabolic diseases are closely associated with insulin resistance. Obesity-induced miRNAs are also considered to be potential contributors to the development of insulin resistance and type 2 diabetes. Previously, the expression of miR-1271 was reported to be upregulated in the liver of d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676082/ https://www.ncbi.nlm.nih.gov/pubmed/29159216 http://dx.doi.org/10.1016/j.dib.2017.10.055 |
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author | Yang, Won-Mo Min, Kyung-Ho Park, Se-Whan Lee, Wan |
author_facet | Yang, Won-Mo Min, Kyung-Ho Park, Se-Whan Lee, Wan |
author_sort | Yang, Won-Mo |
collection | PubMed |
description | Obesity and metabolic diseases are closely associated with insulin resistance. Obesity-induced miRNAs are also considered to be potential contributors to the development of insulin resistance and type 2 diabetes. Previously, the expression of miR-1271 was reported to be upregulated in the liver of diet-induced obese mice (Yang et al., 2016) [1]. In this data article, multiple in silico analysis predicted FOXO1 gene to be a direct target of miR-1271. Dual luciferase reporter gene analysis showed that miR-1271 suppressed FOXO1 expression by direct binding to 3′UTR. The overexpression of miR-1271 reduced the protein expression of FOXO1, thereby reducing the transcription of PEPCK, a downstream target of FOXO1. The data is related to a research article entitled "MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells" (Yang et al., 2016) [1]. |
format | Online Article Text |
id | pubmed-5676082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56760822017-11-20 Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes Yang, Won-Mo Min, Kyung-Ho Park, Se-Whan Lee, Wan Data Brief Cell biology Obesity and metabolic diseases are closely associated with insulin resistance. Obesity-induced miRNAs are also considered to be potential contributors to the development of insulin resistance and type 2 diabetes. Previously, the expression of miR-1271 was reported to be upregulated in the liver of diet-induced obese mice (Yang et al., 2016) [1]. In this data article, multiple in silico analysis predicted FOXO1 gene to be a direct target of miR-1271. Dual luciferase reporter gene analysis showed that miR-1271 suppressed FOXO1 expression by direct binding to 3′UTR. The overexpression of miR-1271 reduced the protein expression of FOXO1, thereby reducing the transcription of PEPCK, a downstream target of FOXO1. The data is related to a research article entitled "MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells" (Yang et al., 2016) [1]. Elsevier 2017-10-28 /pmc/articles/PMC5676082/ /pubmed/29159216 http://dx.doi.org/10.1016/j.dib.2017.10.055 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Cell biology Yang, Won-Mo Min, Kyung-Ho Park, Se-Whan Lee, Wan Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes |
title | Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes |
title_full | Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes |
title_fullStr | Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes |
title_full_unstemmed | Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes |
title_short | Data on the decreased expression of FOXO1 by miR-1271 in HepG2 hepatocytes |
title_sort | data on the decreased expression of foxo1 by mir-1271 in hepg2 hepatocytes |
topic | Cell biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676082/ https://www.ncbi.nlm.nih.gov/pubmed/29159216 http://dx.doi.org/10.1016/j.dib.2017.10.055 |
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