Cargando…
Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus
BACKGROUND: Cytokines are significant in the development and progression of chronic periodontitis (ChP) and type 2 diabetes mellitus (DT2). Insufficient information is available regarding the pro- versus anti-inflammatory cytokines in ChP's influence on systemic levels of cytokines on DT2. This...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676332/ https://www.ncbi.nlm.nih.gov/pubmed/29242686 http://dx.doi.org/10.4103/0972-124X.201694 |
_version_ | 1783277042976948224 |
---|---|
author | Acharya, Anirudh Balakrishna Thakur, Srinath Muddapur, Mahadevayya Veerayya Kulkarni, Raghavendra Dhirendra |
author_facet | Acharya, Anirudh Balakrishna Thakur, Srinath Muddapur, Mahadevayya Veerayya Kulkarni, Raghavendra Dhirendra |
author_sort | Acharya, Anirudh Balakrishna |
collection | PubMed |
description | BACKGROUND: Cytokines are significant in the development and progression of chronic periodontitis (ChP) and type 2 diabetes mellitus (DT2). Insufficient information is available regarding the pro- versus anti-inflammatory cytokines in ChP's influence on systemic levels of cytokines on DT2. This study investigated the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-4 and IL-6 in the serum of patients with ChP, DT2, and with both ChP and DT2, as compared to health. MATERIALS AND METHODS: A total of eighty participants were grouped equally groups as healthy (NH), ChP with, and without DT2 (ChP and ChP + DT2) and only type 2 diabetes (DT2). Plaque and gingival indices, bleeding on probing, pocket probing depths, clinical attachment loss, were evaluated. Serum samples were collected to measure glycated hemoglobin, random blood sugar. TNF-α, IL-4 and -6 was assessed by ELISA. RESULTS: The selected cytokines were detected in all the participants. TNF-α and IL-6 were highest in ChP + DT2 group, whereas IL-4 was highest in health. Significant differences and correlation were observed between the cytokines, periodontal, and glycemic parameters and among the four groups. CONCLUSION: TNF-α and IL-6 appear to heighten the inflammatory state in patients with both type 2 diabetes and periodontitis, but IL-4, though considered an anti-inflammatory mediator was not convincing in such a role in this study. The cytokine behavior needs to be studied further in larger studies. |
format | Online Article Text |
id | pubmed-5676332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56763322017-12-14 Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus Acharya, Anirudh Balakrishna Thakur, Srinath Muddapur, Mahadevayya Veerayya Kulkarni, Raghavendra Dhirendra J Indian Soc Periodontol Original Article BACKGROUND: Cytokines are significant in the development and progression of chronic periodontitis (ChP) and type 2 diabetes mellitus (DT2). Insufficient information is available regarding the pro- versus anti-inflammatory cytokines in ChP's influence on systemic levels of cytokines on DT2. This study investigated the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-4 and IL-6 in the serum of patients with ChP, DT2, and with both ChP and DT2, as compared to health. MATERIALS AND METHODS: A total of eighty participants were grouped equally groups as healthy (NH), ChP with, and without DT2 (ChP and ChP + DT2) and only type 2 diabetes (DT2). Plaque and gingival indices, bleeding on probing, pocket probing depths, clinical attachment loss, were evaluated. Serum samples were collected to measure glycated hemoglobin, random blood sugar. TNF-α, IL-4 and -6 was assessed by ELISA. RESULTS: The selected cytokines were detected in all the participants. TNF-α and IL-6 were highest in ChP + DT2 group, whereas IL-4 was highest in health. Significant differences and correlation were observed between the cytokines, periodontal, and glycemic parameters and among the four groups. CONCLUSION: TNF-α and IL-6 appear to heighten the inflammatory state in patients with both type 2 diabetes and periodontitis, but IL-4, though considered an anti-inflammatory mediator was not convincing in such a role in this study. The cytokine behavior needs to be studied further in larger studies. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5676332/ /pubmed/29242686 http://dx.doi.org/10.4103/0972-124X.201694 Text en Copyright: © 2017 Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Acharya, Anirudh Balakrishna Thakur, Srinath Muddapur, Mahadevayya Veerayya Kulkarni, Raghavendra Dhirendra Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
title | Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
title_full | Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
title_fullStr | Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
title_full_unstemmed | Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
title_short | Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
title_sort | tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676332/ https://www.ncbi.nlm.nih.gov/pubmed/29242686 http://dx.doi.org/10.4103/0972-124X.201694 |
work_keys_str_mv | AT acharyaanirudhbalakrishna tumornecrosisfactorainterleukin4and6intheserumofhealthchronicperiodontitisandtype2diabetesmellitus AT thakursrinath tumornecrosisfactorainterleukin4and6intheserumofhealthchronicperiodontitisandtype2diabetesmellitus AT muddapurmahadevayyaveerayya tumornecrosisfactorainterleukin4and6intheserumofhealthchronicperiodontitisandtype2diabetesmellitus AT kulkarniraghavendradhirendra tumornecrosisfactorainterleukin4and6intheserumofhealthchronicperiodontitisandtype2diabetesmellitus |