Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review

Macrophage activation syndrome (MAS) is a severe, potentially fatal condition that may complicate autoimmune diseases, and it belongs to hemophagocytic lymphohistiocytosis (HLH) disorders. MAS occurs in adults and children. However, it is rare in juvenile systemic lupus erythematosus (jSLE), and it...

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Autores principales: Alkoht, Asaad, Hanafi, Ibrahem, Khalil, Basheer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676417/
https://www.ncbi.nlm.nih.gov/pubmed/29209549
http://dx.doi.org/10.1155/2017/5304180
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author Alkoht, Asaad
Hanafi, Ibrahem
Khalil, Basheer
author_facet Alkoht, Asaad
Hanafi, Ibrahem
Khalil, Basheer
author_sort Alkoht, Asaad
collection PubMed
description Macrophage activation syndrome (MAS) is a severe, potentially fatal condition that may complicate autoimmune diseases, and it belongs to hemophagocytic lymphohistiocytosis (HLH) disorders. MAS occurs in adults and children. However, it is rare in juvenile systemic lupus erythematosus (jSLE), and it is extremely rare to be the initial presentation of jSLE. Here, we report two patients with juvenile SLE who initially presented with MAS. One of the two patients is 4 years old. This is the youngest reported patient to our knowledge.
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spelling pubmed-56764172017-12-05 Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review Alkoht, Asaad Hanafi, Ibrahem Khalil, Basheer Case Rep Rheumatol Case Report Macrophage activation syndrome (MAS) is a severe, potentially fatal condition that may complicate autoimmune diseases, and it belongs to hemophagocytic lymphohistiocytosis (HLH) disorders. MAS occurs in adults and children. However, it is rare in juvenile systemic lupus erythematosus (jSLE), and it is extremely rare to be the initial presentation of jSLE. Here, we report two patients with juvenile SLE who initially presented with MAS. One of the two patients is 4 years old. This is the youngest reported patient to our knowledge. Hindawi 2017 2017-10-25 /pmc/articles/PMC5676417/ /pubmed/29209549 http://dx.doi.org/10.1155/2017/5304180 Text en Copyright © 2017 Asaad Alkoht et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alkoht, Asaad
Hanafi, Ibrahem
Khalil, Basheer
Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
title Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
title_full Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
title_fullStr Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
title_full_unstemmed Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
title_short Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
title_sort macrophage activation syndrome: a report of two cases and a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676417/
https://www.ncbi.nlm.nih.gov/pubmed/29209549
http://dx.doi.org/10.1155/2017/5304180
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