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Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review
The aim of this study is to investigate the effect of statins type or even when grouping statins by hydrophilic or hydrophobic nature on prostate cancer risk. A literature search was performed without language restrictions using the databases of PubMed (1984.1–2015.3), MEDLINE (1984.1–2015.3), and E...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676426/ https://www.ncbi.nlm.nih.gov/pubmed/27924788 http://dx.doi.org/10.4103/1008-682X.190327 |
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author | Tan, Ping Zhang, Chen Wei, Shi-You Tang, Zhuang Gao, Liang Yang, Lu Wei, Qiang |
author_facet | Tan, Ping Zhang, Chen Wei, Shi-You Tang, Zhuang Gao, Liang Yang, Lu Wei, Qiang |
author_sort | Tan, Ping |
collection | PubMed |
description | The aim of this study is to investigate the effect of statins type or even when grouping statins by hydrophilic or hydrophobic nature on prostate cancer risk. A literature search was performed without language restrictions using the databases of PubMed (1984.1–2015.3), MEDLINE (1984.1–2015.3), and EMBASE (1990.1–2015.3). Two independent reviewers appraised eligible studies and extracted data. Weighted averages were reported as relative risk (RR) with 95% confidence intervals (CI). Statistic heterogeneity scores were assessed with the standard Cochran's Q-test and I(2) statistic. Publication bias was detected using the Begg's and Egger's tests. All statistical analyses were conducted by STATA version 10. Finally, fourteen studies were included in the meta-analysis. Both hydrophilic and hydrophobic statins showed no association with incidence of prostate cancer (RR = 1.00, 95% CI: 0.82–1.17; RR = 0.90, 95% CI: 0.73–1.08, respectively). Meanwhile, the risk of prostate cancer was not reduced in simvastatin (RR = 0.89, 95% CI: 0.72–1.05), pravastatin (RR = 1.02, 95% CI: 0.94–1.11), atorvastatin (RR = 0.89, 95% CI: 0.76–1.02), fluvastatin (RR = 0.99, 95% CI: 0.97–1.01), or lovastatin users (RR = 0.94, 95% CI: 0.79–1.08). The funnel plot showed that there was no publication bias. The results showed that statins had a neutral effect on prostate cancer risk; hydrophilic and hydrophobic statins as well as any subtype of statins did not affect the risk of prostate cancer. |
format | Online Article Text |
id | pubmed-5676426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56764262017-11-17 Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review Tan, Ping Zhang, Chen Wei, Shi-You Tang, Zhuang Gao, Liang Yang, Lu Wei, Qiang Asian J Androl Original Article The aim of this study is to investigate the effect of statins type or even when grouping statins by hydrophilic or hydrophobic nature on prostate cancer risk. A literature search was performed without language restrictions using the databases of PubMed (1984.1–2015.3), MEDLINE (1984.1–2015.3), and EMBASE (1990.1–2015.3). Two independent reviewers appraised eligible studies and extracted data. Weighted averages were reported as relative risk (RR) with 95% confidence intervals (CI). Statistic heterogeneity scores were assessed with the standard Cochran's Q-test and I(2) statistic. Publication bias was detected using the Begg's and Egger's tests. All statistical analyses were conducted by STATA version 10. Finally, fourteen studies were included in the meta-analysis. Both hydrophilic and hydrophobic statins showed no association with incidence of prostate cancer (RR = 1.00, 95% CI: 0.82–1.17; RR = 0.90, 95% CI: 0.73–1.08, respectively). Meanwhile, the risk of prostate cancer was not reduced in simvastatin (RR = 0.89, 95% CI: 0.72–1.05), pravastatin (RR = 1.02, 95% CI: 0.94–1.11), atorvastatin (RR = 0.89, 95% CI: 0.76–1.02), fluvastatin (RR = 0.99, 95% CI: 0.97–1.01), or lovastatin users (RR = 0.94, 95% CI: 0.79–1.08). The funnel plot showed that there was no publication bias. The results showed that statins had a neutral effect on prostate cancer risk; hydrophilic and hydrophobic statins as well as any subtype of statins did not affect the risk of prostate cancer. Medknow Publications & Media Pvt Ltd 2017 2016-12-02 /pmc/articles/PMC5676426/ /pubmed/27924788 http://dx.doi.org/10.4103/1008-682X.190327 Text en Copyright: © The Author(s)(2017) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Tan, Ping Zhang, Chen Wei, Shi-You Tang, Zhuang Gao, Liang Yang, Lu Wei, Qiang Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
title | Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
title_full | Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
title_fullStr | Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
title_full_unstemmed | Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
title_short | Effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
title_sort | effect of statins type on incident prostate cancer risk: a meta-analysis and systematic review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676426/ https://www.ncbi.nlm.nih.gov/pubmed/27924788 http://dx.doi.org/10.4103/1008-682X.190327 |
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