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Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism

TRPML1 channel is a non-selective group-2 transient receptor potential (TRP) channel with Ca(2+) permeability. Located mainly in late endosome and lysosome of all mammalian cell types, TRPML1 is indispensable in the processes of endocytosis, membrane trafficking, and lysosome biogenesis. Mutations o...

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Detalles Bibliográficos
Autores principales:	Zhang, Sensen, Li, Ningning, Zeng, Wenwen, Gao, Ning, Yang, Maojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676595/ https://www.ncbi.nlm.nih.gov/pubmed/28936784 http://dx.doi.org/10.1007/s13238-017-0476-5

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