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Biosensing Using Magnetic Particle Detection Techniques

Magnetic particles are widely used as signal labels in a variety of biological sensing applications, such as molecular detection and related strategies that rely on ligand-receptor binding. In this review, we explore the fundamental concepts involved in designing magnetic particles for biosensing ap...

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Autores principales: Chen, Yi-Ting, Kolhatkar, Arati G., Zenasni, Oussama, Xu, Shoujun, Lee, T. Randall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676660/
https://www.ncbi.nlm.nih.gov/pubmed/28994727
http://dx.doi.org/10.3390/s17102300
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author Chen, Yi-Ting
Kolhatkar, Arati G.
Zenasni, Oussama
Xu, Shoujun
Lee, T. Randall
author_facet Chen, Yi-Ting
Kolhatkar, Arati G.
Zenasni, Oussama
Xu, Shoujun
Lee, T. Randall
author_sort Chen, Yi-Ting
collection PubMed
description Magnetic particles are widely used as signal labels in a variety of biological sensing applications, such as molecular detection and related strategies that rely on ligand-receptor binding. In this review, we explore the fundamental concepts involved in designing magnetic particles for biosensing applications and the techniques used to detect them. First, we briefly describe the magnetic properties that are important for bio-sensing applications and highlight the associated key parameters (such as the starting materials, size, functionalization methods, and bio-conjugation strategies). Subsequently, we focus on magnetic sensing applications that utilize several types of magnetic detection techniques: spintronic sensors, nuclear magnetic resonance (NMR) sensors, superconducting quantum interference devices (SQUIDs), sensors based on the atomic magnetometer (AM), and others. From the studies reported, we note that the size of the MPs is one of the most important factors in choosing a sensing technique.
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spelling pubmed-56766602017-11-17 Biosensing Using Magnetic Particle Detection Techniques Chen, Yi-Ting Kolhatkar, Arati G. Zenasni, Oussama Xu, Shoujun Lee, T. Randall Sensors (Basel) Review Magnetic particles are widely used as signal labels in a variety of biological sensing applications, such as molecular detection and related strategies that rely on ligand-receptor binding. In this review, we explore the fundamental concepts involved in designing magnetic particles for biosensing applications and the techniques used to detect them. First, we briefly describe the magnetic properties that are important for bio-sensing applications and highlight the associated key parameters (such as the starting materials, size, functionalization methods, and bio-conjugation strategies). Subsequently, we focus on magnetic sensing applications that utilize several types of magnetic detection techniques: spintronic sensors, nuclear magnetic resonance (NMR) sensors, superconducting quantum interference devices (SQUIDs), sensors based on the atomic magnetometer (AM), and others. From the studies reported, we note that the size of the MPs is one of the most important factors in choosing a sensing technique. MDPI 2017-10-10 /pmc/articles/PMC5676660/ /pubmed/28994727 http://dx.doi.org/10.3390/s17102300 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yi-Ting
Kolhatkar, Arati G.
Zenasni, Oussama
Xu, Shoujun
Lee, T. Randall
Biosensing Using Magnetic Particle Detection Techniques
title Biosensing Using Magnetic Particle Detection Techniques
title_full Biosensing Using Magnetic Particle Detection Techniques
title_fullStr Biosensing Using Magnetic Particle Detection Techniques
title_full_unstemmed Biosensing Using Magnetic Particle Detection Techniques
title_short Biosensing Using Magnetic Particle Detection Techniques
title_sort biosensing using magnetic particle detection techniques
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676660/
https://www.ncbi.nlm.nih.gov/pubmed/28994727
http://dx.doi.org/10.3390/s17102300
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