Leptin regulates Granzyme-A, PD-1 and CTLA-4 expression in T cell to control visceral leishmaniasis in BALB/c Mice

Visceral leishmaniasis (VL) is responsible for several deaths in malnourished children accompanied by diminished circulating leptin and impaired cell-mediated immunity. Typically, leptin deficiency is associated with the Th2 polarization that markedly coincides with the pathogenesis of VL. The aim o...

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Detalles Bibliográficos
Autores principales: Dayakar, Alti, Chandrasekaran, Sambamurthy, Veronica, Jalaja, Bharadwaja, Vadloori, Maurya, Radheshyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676676/
https://www.ncbi.nlm.nih.gov/pubmed/29116252
http://dx.doi.org/10.1038/s41598-017-15288-7

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