Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer

Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active promoters and is associated with oncogene activation in prostate cancer, but its role in enhancer function is still poorly understood. Here we show that H2A.Zac containing nucleosomes are commonly redistributed to neo-enhancers in c...

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Detalles Bibliográficos
Autores principales: Valdés-Mora, Fátima, Gould, Cathryn M., Colino-Sanguino, Yolanda, Qu, Wenjia, Song, Jenny Z., Taylor, Kylie M., Buske, Fabian A., Statham, Aaron L., Nair, Shalima S., Armstrong, Nicola J., Kench, James G., Lee, Kenneth M. L., Horvath, Lisa G., Qiu, Minru, Ilinykh, Alexei, Yeo-Teh, Nicole S., Gallego-Ortega, David, Stirzaker, Clare, Clark, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676741/
https://www.ncbi.nlm.nih.gov/pubmed/29116202
http://dx.doi.org/10.1038/s41467-017-01393-8

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