Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the cytoskeletal protein β-III-spectrin. Previously, a SCA5 mutation resulting in a leucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was shown to cause a 1000-fold increase in actin-bi...

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Detalles Bibliográficos
Autores principales: Avery, Adam W., Fealey, Michael E., Wang, Fengbin, Orlova, Albina, Thompson, Andrew R., Thomas, David D., Hays, Thomas S., Egelman, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676748/
https://www.ncbi.nlm.nih.gov/pubmed/29116080
http://dx.doi.org/10.1038/s41467-017-01367-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676748/
https://www.ncbi.nlm.nih.gov/pubmed/29116080
http://dx.doi.org/10.1038/s41467-017-01367-w

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