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Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming
The bilateral anterior temporal lobes play a key role in semantic representation. This is clearly demonstrated by the performance of patients with semantic dementia, a disorder characterised by a progressive and selective decline in semantic memory over all modalities as a result of anterior tempora...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676810/ https://www.ncbi.nlm.nih.gov/pubmed/28756485 http://dx.doi.org/10.1007/s00429-017-1430-2 |
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author | Woollams, Anna M. J. Lindley, Lee Pobric, Gorana Hoffman, Paul |
author_facet | Woollams, Anna M. J. Lindley, Lee Pobric, Gorana Hoffman, Paul |
author_sort | Woollams, Anna M. |
collection | PubMed |
description | The bilateral anterior temporal lobes play a key role in semantic representation. This is clearly demonstrated by the performance of patients with semantic dementia, a disorder characterised by a progressive and selective decline in semantic memory over all modalities as a result of anterior temporal atrophy. Although all patients exhibit a progressive decline in both single-word production and comprehension, those with greater atrophy to the left anterior temporal lobe show a stronger decline in word production than comprehension. This asymmetry has been attributed to the greater connectivity of the left anterior temporal lobe with left-lateralised speech production mechanisms. Virtual lesioning of the left ATL using offline repetitive transcranial magnetic stimulation (rTMS) has been shown to disrupt picture naming, but, the impact of right ATL rTMS is yet to be explored. We tested the prediction that disruption of picture naming in normal participants by rTMS should be greater for the left than the right ATL. We found a significant increase in picture naming latencies specifically for stimulation of the left ATL only. Neither left nor right ATL TMS slowed performance in a number naming control task. These results support the hypothesis that although both temporal lobes are part of a widespread semantic network in the human brain, the left anterior temporal lobe possesses a stronger connection to left-lateralised speech production areas than the right temporal lobe. |
format | Online Article Text |
id | pubmed-5676810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-56768102017-11-21 Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming Woollams, Anna M. J. Lindley, Lee Pobric, Gorana Hoffman, Paul Brain Struct Funct Original Article The bilateral anterior temporal lobes play a key role in semantic representation. This is clearly demonstrated by the performance of patients with semantic dementia, a disorder characterised by a progressive and selective decline in semantic memory over all modalities as a result of anterior temporal atrophy. Although all patients exhibit a progressive decline in both single-word production and comprehension, those with greater atrophy to the left anterior temporal lobe show a stronger decline in word production than comprehension. This asymmetry has been attributed to the greater connectivity of the left anterior temporal lobe with left-lateralised speech production mechanisms. Virtual lesioning of the left ATL using offline repetitive transcranial magnetic stimulation (rTMS) has been shown to disrupt picture naming, but, the impact of right ATL rTMS is yet to be explored. We tested the prediction that disruption of picture naming in normal participants by rTMS should be greater for the left than the right ATL. We found a significant increase in picture naming latencies specifically for stimulation of the left ATL only. Neither left nor right ATL TMS slowed performance in a number naming control task. These results support the hypothesis that although both temporal lobes are part of a widespread semantic network in the human brain, the left anterior temporal lobe possesses a stronger connection to left-lateralised speech production areas than the right temporal lobe. Springer Berlin Heidelberg 2017-07-29 2017 /pmc/articles/PMC5676810/ /pubmed/28756485 http://dx.doi.org/10.1007/s00429-017-1430-2 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Woollams, Anna M. J. Lindley, Lee Pobric, Gorana Hoffman, Paul Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
title | Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
title_full | Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
title_fullStr | Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
title_full_unstemmed | Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
title_short | Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
title_sort | laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676810/ https://www.ncbi.nlm.nih.gov/pubmed/28756485 http://dx.doi.org/10.1007/s00429-017-1430-2 |
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