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Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease

BACKGROUND: Determinants of early-onset Alzheimer’s disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We s...

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Autores principales: Chen, Yaohua, Sillaire, Adeline Rollin, Dallongeville, Jean, Skrobala, Emilie, Wallon, David, Dubois, Bruno, Hannequin, Didier, Pasquier, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676853/
https://www.ncbi.nlm.nih.gov/pubmed/28984595
http://dx.doi.org/10.3233/JAD-170367
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author Chen, Yaohua
Sillaire, Adeline Rollin
Dallongeville, Jean
Skrobala, Emilie
Wallon, David
Dubois, Bruno
Hannequin, Didier
Pasquier, Florence
author_facet Chen, Yaohua
Sillaire, Adeline Rollin
Dallongeville, Jean
Skrobala, Emilie
Wallon, David
Dubois, Bruno
Hannequin, Didier
Pasquier, Florence
author_sort Chen, Yaohua
collection PubMed
description BACKGROUND: Determinants of early-onset Alzheimer’s disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007). Demographic data, VRFs, comorbidities, treatments, and APOE genotypes were compared in multivariable logistic regression analyses. RESULTS: We studied 102 participants with dementia (mean±standard deviation age: 59.5±3.8; women: 59.8%) and 306 controls. Compared with controls, EOAD participants had spent less time in formal education (9.9±2.9 versus 11.7±3.8 y; p < 0.0001), were less likely to be regular alcohol consumers (p < 0.0001), had a lower body mass index (–2 kg/m(2); p < 0.0004), and a lower mean systolic blood pressure (–6.2 mmHg; p = 0.0036). The prevalence of APOE ɛ4 allele was higher in participants with dementia than in controls (50% versus 29.4%; p = 0.0002), as was the prevalence of depression (48% versus 32%; p < 0.001). Similar results were observed in multivariable analysis. Compared with EOAD participants lacking VRFs, EOAD participants with at least one VRF had a higher prevalence of depression (29.6% versus 53.3%, respectively; p = 0.03). CONCLUSION: The prevalence of VRFs is not elevated in EOAD patients (in contrast to older AD patients). Extensive genetic testing should be considered more frequently in the context of EOAD.
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spelling pubmed-56768532017-11-16 Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease Chen, Yaohua Sillaire, Adeline Rollin Dallongeville, Jean Skrobala, Emilie Wallon, David Dubois, Bruno Hannequin, Didier Pasquier, Florence J Alzheimers Dis Research Article BACKGROUND: Determinants of early-onset Alzheimer’s disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007). Demographic data, VRFs, comorbidities, treatments, and APOE genotypes were compared in multivariable logistic regression analyses. RESULTS: We studied 102 participants with dementia (mean±standard deviation age: 59.5±3.8; women: 59.8%) and 306 controls. Compared with controls, EOAD participants had spent less time in formal education (9.9±2.9 versus 11.7±3.8 y; p < 0.0001), were less likely to be regular alcohol consumers (p < 0.0001), had a lower body mass index (–2 kg/m(2); p < 0.0004), and a lower mean systolic blood pressure (–6.2 mmHg; p = 0.0036). The prevalence of APOE ɛ4 allele was higher in participants with dementia than in controls (50% versus 29.4%; p = 0.0002), as was the prevalence of depression (48% versus 32%; p < 0.001). Similar results were observed in multivariable analysis. Compared with EOAD participants lacking VRFs, EOAD participants with at least one VRF had a higher prevalence of depression (29.6% versus 53.3%, respectively; p = 0.03). CONCLUSION: The prevalence of VRFs is not elevated in EOAD patients (in contrast to older AD patients). Extensive genetic testing should be considered more frequently in the context of EOAD. IOS Press 2017-10-03 /pmc/articles/PMC5676853/ /pubmed/28984595 http://dx.doi.org/10.3233/JAD-170367 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Yaohua
Sillaire, Adeline Rollin
Dallongeville, Jean
Skrobala, Emilie
Wallon, David
Dubois, Bruno
Hannequin, Didier
Pasquier, Florence
Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease
title Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease
title_full Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease
title_fullStr Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease
title_full_unstemmed Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease
title_short Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer’s Disease
title_sort low prevalence and clinical effect of vascular risk factors in early-onset alzheimer’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676853/
https://www.ncbi.nlm.nih.gov/pubmed/28984595
http://dx.doi.org/10.3233/JAD-170367
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