Cargando…
c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential
Although the etiology of Parkinson’s disease (PD) is poorly understood, oxidative stress has long been implicated in the pathogenesis of the disease. However, multifaceted and divergent signaling cascades downstream of oxidative stress have posed challenges for researchers to identify a central com...
Autores principales: | Brahmachari, Saurav, Karuppagounder, Senthilkumar S., Ge, Preston, Lee, Saebom, Dawson, Valina L., Dawson, Ted M., Ko, Han Seok |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676866/ https://www.ncbi.nlm.nih.gov/pubmed/29103051 http://dx.doi.org/10.3233/JPD-171191 |
Ejemplares similares
-
The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
por: Karuppagounder, Senthilkumar S., et al.
Publicado: (2014) -
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons
por: Kumar, Manoj, et al.
Publicado: (2020) -
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
por: Yun, Seung Pil, et al.
Publicado: (2018) -
The cell biology of Parkinson’s disease
por: Panicker, Nikhil, et al.
Publicado: (2021) -
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
por: Hinkle, Jared T., et al.
Publicado: (2022)