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Mutagenic cost of ribonucleotides in bacterial DNA

Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximately once every 2,000 base pairs synthesized. Ribonucleotide excision repair (RER) removes ribonucleoside monophosphates (rNMPs) from genomic DNA, replacing the error with the appropriate deoxyribonucle...

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Detalles Bibliográficos
Autores principales:	Schroeder, Jeremy W., Randall, Justin R., Hirst, William G., O’Donnell, Michael E., Simmons, Lyle A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676920/ https://www.ncbi.nlm.nih.gov/pubmed/29078353 http://dx.doi.org/10.1073/pnas.1710995114

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