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Ventricular depolarisation vectors in exercise induced myocardial ischaemia
Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals. Here we...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676957/ https://www.ncbi.nlm.nih.gov/pubmed/29116106 http://dx.doi.org/10.1038/s41598-017-14865-0 |
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author | Vellani, Cameruddin W. Yusuf, Mohammad Mahmud, Sadia Hashmi, Satwat |
author_facet | Vellani, Cameruddin W. Yusuf, Mohammad Mahmud, Sadia Hashmi, Satwat |
author_sort | Vellani, Cameruddin W. |
collection | PubMed |
description | Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals. Here we show a method for obtaining the coordinates of resultant electrical forces during exercise derived from a bipolar orthogonal lead system for calculation of electrical vectors in three planes. In a trial, analysis of changes in vectors indicated that the extent of reduction in magnitude with exercise was significantly greater in groups of patients categorized by impaired effort tolerance and signs of ischaemia. Measurement of changes in the spectrum of depolarisation vectors during exercise has the potential for non-invasive assessment of myocardial ischaemia. This could be the basis of a portable, low-cost tool for investigation of patients with symptoms suggestive of coronary artery disease. |
format | Online Article Text |
id | pubmed-5676957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56769572017-11-15 Ventricular depolarisation vectors in exercise induced myocardial ischaemia Vellani, Cameruddin W. Yusuf, Mohammad Mahmud, Sadia Hashmi, Satwat Sci Rep Article Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals. Here we show a method for obtaining the coordinates of resultant electrical forces during exercise derived from a bipolar orthogonal lead system for calculation of electrical vectors in three planes. In a trial, analysis of changes in vectors indicated that the extent of reduction in magnitude with exercise was significantly greater in groups of patients categorized by impaired effort tolerance and signs of ischaemia. Measurement of changes in the spectrum of depolarisation vectors during exercise has the potential for non-invasive assessment of myocardial ischaemia. This could be the basis of a portable, low-cost tool for investigation of patients with symptoms suggestive of coronary artery disease. Nature Publishing Group UK 2017-11-07 /pmc/articles/PMC5676957/ /pubmed/29116106 http://dx.doi.org/10.1038/s41598-017-14865-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Vellani, Cameruddin W. Yusuf, Mohammad Mahmud, Sadia Hashmi, Satwat Ventricular depolarisation vectors in exercise induced myocardial ischaemia |
title | Ventricular depolarisation vectors in exercise induced myocardial ischaemia |
title_full | Ventricular depolarisation vectors in exercise induced myocardial ischaemia |
title_fullStr | Ventricular depolarisation vectors in exercise induced myocardial ischaemia |
title_full_unstemmed | Ventricular depolarisation vectors in exercise induced myocardial ischaemia |
title_short | Ventricular depolarisation vectors in exercise induced myocardial ischaemia |
title_sort | ventricular depolarisation vectors in exercise induced myocardial ischaemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676957/ https://www.ncbi.nlm.nih.gov/pubmed/29116106 http://dx.doi.org/10.1038/s41598-017-14865-0 |
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