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A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inacce...

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Detalles Bibliográficos
Autor principal: Tofaris, George K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676982/
https://www.ncbi.nlm.nih.gov/pubmed/28922170
http://dx.doi.org/10.3233/JPD-171176
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author Tofaris, George K.
author_facet Tofaris, George K.
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description Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson’s disease pathophysiology and their potential as disease biomarkers.
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spelling pubmed-56769822017-11-16 A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease Tofaris, George K. J Parkinsons Dis Review Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson’s disease pathophysiology and their potential as disease biomarkers. IOS Press 2017-11-01 /pmc/articles/PMC5676982/ /pubmed/28922170 http://dx.doi.org/10.3233/JPD-171176 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Tofaris, George K.
A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
title A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
title_full A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
title_fullStr A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
title_full_unstemmed A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
title_short A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
title_sort critical assessment of exosomes in the pathogenesis and stratification of parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676982/
https://www.ncbi.nlm.nih.gov/pubmed/28922170
http://dx.doi.org/10.3233/JPD-171176
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