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A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inacce...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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IOS Press
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676982/ https://www.ncbi.nlm.nih.gov/pubmed/28922170 http://dx.doi.org/10.3233/JPD-171176 |
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author | Tofaris, George K. |
author_facet | Tofaris, George K. |
author_sort | Tofaris, George K. |
collection | PubMed |
description | Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson’s disease pathophysiology and their potential as disease biomarkers. |
format | Online Article Text |
id | pubmed-5676982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56769822017-11-16 A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease Tofaris, George K. J Parkinsons Dis Review Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson’s disease pathophysiology and their potential as disease biomarkers. IOS Press 2017-11-01 /pmc/articles/PMC5676982/ /pubmed/28922170 http://dx.doi.org/10.3233/JPD-171176 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Tofaris, George K. A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease |
title | A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease |
title_full | A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease |
title_fullStr | A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease |
title_full_unstemmed | A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease |
title_short | A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease |
title_sort | critical assessment of exosomes in the pathogenesis and stratification of parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676982/ https://www.ncbi.nlm.nih.gov/pubmed/28922170 http://dx.doi.org/10.3233/JPD-171176 |
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