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The voltage sensor of excitation–contraction coupling in mammals: Inactivation and interaction with Ca(2+)
In skeletal muscle, the four-helix voltage-sensing modules (VSMs) of Ca(V)1.1 calcium channels simultaneously gate two Ca(2+) pathways: the Ca(V)1.1 pore itself and the RyR1 calcium release channel in the sarcoplasmic reticulum. Here, to gain insight into the mechanism by which VSMs gate RyR1, we qu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677103/ https://www.ncbi.nlm.nih.gov/pubmed/29021148 http://dx.doi.org/10.1085/jgp.201611725 |