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Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice

β-carotene oxygenase 2 (BCO2) is a carotenoid cleavage enzyme located in the inner mitochondrial membrane. Ablation of BCO2 impairs mitochondrial function leading to oxidative stress. Herein, we performed a targeted metabolomics study using ultrahigh performance liquid chromatography-tandem mass spe...

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Detalles Bibliográficos
Autores principales:	Wu, Lei, Guo, Xin, Lyu, Yi, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Hildebrand, Deana, Wang, Weiqun, Medeiros, Denis M., Shen, Xinchun, Lin, Dingbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677115/ https://www.ncbi.nlm.nih.gov/pubmed/29116185 http://dx.doi.org/10.1038/s41598-017-15222-x

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