Cargando…

Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)

Identification of quantitative trait loci (QTL) involved in the variation of hybrid value is of key importance for cross-pollinated species such as maize (Zea mays L.). In a companion paper, we illustrated a new QTL mapping population design involving a factorial mating between two multiparental seg...

Descripción completa

Detalles Bibliográficos
Autores principales: Giraud, Héloïse, Bauland, Cyril, Falque, Matthieu, Madur, Delphine, Combes, Valérie, Jamin, Philippe, Monteil, Cécile, Laborde, Jacques, Palaffre, Carine, Gaillard, Antoine, Blanchard, Philippe, Charcosset, Alain, Moreau, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677153/
https://www.ncbi.nlm.nih.gov/pubmed/28963164
http://dx.doi.org/10.1534/g3.117.300121
_version_ 1783277185011810304
author Giraud, Héloïse
Bauland, Cyril
Falque, Matthieu
Madur, Delphine
Combes, Valérie
Jamin, Philippe
Monteil, Cécile
Laborde, Jacques
Palaffre, Carine
Gaillard, Antoine
Blanchard, Philippe
Charcosset, Alain
Moreau, Laurence
author_facet Giraud, Héloïse
Bauland, Cyril
Falque, Matthieu
Madur, Delphine
Combes, Valérie
Jamin, Philippe
Monteil, Cécile
Laborde, Jacques
Palaffre, Carine
Gaillard, Antoine
Blanchard, Philippe
Charcosset, Alain
Moreau, Laurence
author_sort Giraud, Héloïse
collection PubMed
description Identification of quantitative trait loci (QTL) involved in the variation of hybrid value is of key importance for cross-pollinated species such as maize (Zea mays L.). In a companion paper, we illustrated a new QTL mapping population design involving a factorial mating between two multiparental segregating populations. Six biparental line populations were developed from four founder lines in the Dent and Flint heterotic groups. They were crossed to produce 951 hybrids and evaluated for silage performances. Previously, a linkage analysis (LA) model that assumes each founder line carries a different allele was used to detect QTL involved in General and Specific Combining Abilities (GCA and SCA, respectively) of hybrid value. This previously introduced model requires the estimation of numerous effects per locus, potentially affecting QTL detection power. Using the same design, we compared this “Founder alleles” model to two more parsimonious models, which assume that (i) identity in state at SNP alleles from the same heterotic group implies identity by descent (IBD) at linked QTL (“SNP within-group” model) or (ii) identity in state implies IBD, regardless of population origin of the alleles (“Hybrid genotype” model). This last model assumes biallelic QTL with equal effects in each group. It detected more QTL on average than the two other models but explained lower percentages of variance. The “SNP within-group” model appeared to be a good compromise between the two other models. These results confirm the divergence between the Dent and Flint groups. They also illustrate the need to adapt the QTL detection model to the complexity of the allelic variation, which depends on the trait, the QTL, and the divergence between the heterotic groups.
format Online
Article
Text
id pubmed-5677153
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Genetics Society of America
record_format MEDLINE/PubMed
spelling pubmed-56771532017-11-09 Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.) Giraud, Héloïse Bauland, Cyril Falque, Matthieu Madur, Delphine Combes, Valérie Jamin, Philippe Monteil, Cécile Laborde, Jacques Palaffre, Carine Gaillard, Antoine Blanchard, Philippe Charcosset, Alain Moreau, Laurence G3 (Bethesda) Multiparental Populations Identification of quantitative trait loci (QTL) involved in the variation of hybrid value is of key importance for cross-pollinated species such as maize (Zea mays L.). In a companion paper, we illustrated a new QTL mapping population design involving a factorial mating between two multiparental segregating populations. Six biparental line populations were developed from four founder lines in the Dent and Flint heterotic groups. They were crossed to produce 951 hybrids and evaluated for silage performances. Previously, a linkage analysis (LA) model that assumes each founder line carries a different allele was used to detect QTL involved in General and Specific Combining Abilities (GCA and SCA, respectively) of hybrid value. This previously introduced model requires the estimation of numerous effects per locus, potentially affecting QTL detection power. Using the same design, we compared this “Founder alleles” model to two more parsimonious models, which assume that (i) identity in state at SNP alleles from the same heterotic group implies identity by descent (IBD) at linked QTL (“SNP within-group” model) or (ii) identity in state implies IBD, regardless of population origin of the alleles (“Hybrid genotype” model). This last model assumes biallelic QTL with equal effects in each group. It detected more QTL on average than the two other models but explained lower percentages of variance. The “SNP within-group” model appeared to be a good compromise between the two other models. These results confirm the divergence between the Dent and Flint groups. They also illustrate the need to adapt the QTL detection model to the complexity of the allelic variation, which depends on the trait, the QTL, and the divergence between the heterotic groups. Genetics Society of America 2017-09-28 /pmc/articles/PMC5677153/ /pubmed/28963164 http://dx.doi.org/10.1534/g3.117.300121 Text en Copyright © 2017 Giraud et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Multiparental Populations
Giraud, Héloïse
Bauland, Cyril
Falque, Matthieu
Madur, Delphine
Combes, Valérie
Jamin, Philippe
Monteil, Cécile
Laborde, Jacques
Palaffre, Carine
Gaillard, Antoine
Blanchard, Philippe
Charcosset, Alain
Moreau, Laurence
Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)
title Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)
title_full Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)
title_fullStr Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)
title_full_unstemmed Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)
title_short Linkage Analysis and Association Mapping QTL Detection Models for Hybrids Between Multiparental Populations from Two Heterotic Groups: Application to Biomass Production in Maize (Zea mays L.)
title_sort linkage analysis and association mapping qtl detection models for hybrids between multiparental populations from two heterotic groups: application to biomass production in maize (zea mays l.)
topic Multiparental Populations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677153/
https://www.ncbi.nlm.nih.gov/pubmed/28963164
http://dx.doi.org/10.1534/g3.117.300121
work_keys_str_mv AT giraudheloise linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT baulandcyril linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT falquematthieu linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT madurdelphine linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT combesvalerie linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT jaminphilippe linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT monteilcecile linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT labordejacques linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT palaffrecarine linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT gaillardantoine linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT blanchardphilippe linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT charcossetalain linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl
AT moreaulaurence linkageanalysisandassociationmappingqtldetectionmodelsforhybridsbetweenmultiparentalpopulationsfromtwoheteroticgroupsapplicationtobiomassproductioninmaizezeamaysl