S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics

S-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar...

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Autores principales: Tsikas, Dimitrios, Hanff, Erik, Bollenbach, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Letters To The Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677202/
https://www.ncbi.nlm.nih.gov/pubmed/29142482
http://dx.doi.org/10.3748/wjg.v23.i40.7343
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author Tsikas, Dimitrios
Hanff, Erik
Bollenbach, Alexander
author_facet Tsikas, Dimitrios
Hanff, Erik
Bollenbach, Alexander
author_sort Tsikas, Dimitrios
collection PubMed
description S-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.
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spelling pubmed-56772022017-11-15 S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics Tsikas, Dimitrios Hanff, Erik Bollenbach, Alexander World J Gastroenterol Letters To The Editor S-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated. Baishideng Publishing Group Inc 2017-10-28 2017-10-28 /pmc/articles/PMC5677202/ /pubmed/29142482 http://dx.doi.org/10.3748/wjg.v23.i40.7343 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Letters To The Editor
Tsikas, Dimitrios
Hanff, Erik
Bollenbach, Alexander
S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
title S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
title_full S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
title_fullStr S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
title_full_unstemmed S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
title_short S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
title_sort s-adenosyl-l-methionine towards hepatitis c virus expression: need to consider s-adenosyl-l-methionine’s chemistry, physiology and pharmacokinetics
topic Letters To The Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677202/
https://www.ncbi.nlm.nih.gov/pubmed/29142482
http://dx.doi.org/10.3748/wjg.v23.i40.7343
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