Cargando…

S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics

S-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsikas, Dimitrios, Hanff, Erik, Bollenbach, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2017
Materias:	Letters To The Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677202/ https://www.ncbi.nlm.nih.gov/pubmed/29142482 http://dx.doi.org/10.3748/wjg.v23.i40.7343

Ejemplares similares

Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
por: Rudenko, A. Yu., et al.
Publicado: (2022)

Pharmacokinetic properties of a novel formulation of S-adenosyl-l-methionine phytate
por: Francioso, Antonio, et al.
Publicado: (2021)

Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL
por: Ding, Wei, et al.
Publicado: (2016)

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
por: Steketee, Pieter C., et al.
Publicado: (2018)

S‐Adenosyl‐l‐Methionine Salvage Impacts Psilocybin Formation in “Magic” Mushrooms
por: Demmler, Richard, et al.
Publicado: (2020)

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
por: Noble, Christian G., et al.
Publicado: (2014)

S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects
por: Ogawa, Takafumi, et al.
Publicado: (2022)

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
por: Obata, Fumiaki, et al.
Publicado: (2015)

S-Adenosyl-L-Methionine and Cu(II) Impact Green Plant Regeneration Efficiency
por: Orłowska, Renata, et al.
Publicado: (2022)

Enhancing the production of S-adenosyl-L-methionine in Pichia pastoris GS115 by metabolic engineering
por: Yu, Ping, et al.
Publicado: (2012)

Metabolome analysis of Saccharomyces cerevisiae and optimization of culture medium for S-adenosyl-l-methionine production
por: Hayakawa, Kenshi, et al.
Publicado: (2016)

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase
por: Zhang, Zhengan, et al.
Publicado: (2017)

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling
por: Greco, Carolina Magdalen, et al.
Publicado: (2020)

Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase
por: Tsao, Douglas, et al.
Publicado: (2011)

Automated One-pot Radiosynthesis of [(11)C]S-adenosyl Methionine
por: Zoppolo, Florencia, et al.
Publicado: (2017)

The Key Intermediate in Radical S-Adenosyl-methionine Catalysis: Caught in the Act
por: Rittle, Jonathan
Publicado: (2019)

Structure of the Thiostrepton Resistance Methyltransferase·S-Adenosyl-l-methionine Complex and Its Interaction with Ribosomal RNA
por: Dunstan, Mark S., et al.
Publicado: (2009)

Structural and functional studies of S-adenosyl-L-methionine binding proteins: a ligand-centric approach
por: Gana, Rajaram, et al.
Publicado: (2013)

S-Adenosyl-L-Methionine for the Treatment of Chronic Liver Disease: A Systematic Review and Meta-Analysis
por: Guo, Tao, et al.
Publicado: (2015)

Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages
por: Guo, Tao, et al.
Publicado: (2016)

Rapid and Quantitative Determination of S-Adenosyl-L-Methionine in the Fermentation Process by Surface-Enhanced Raman Scattering
por: Ren, Hairui, et al.
Publicado: (2016)

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis
por: Byer, Amanda S., et al.
Publicado: (2018)

Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes
por: Miller, Sven A., et al.
Publicado: (2019)

Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis
por: Hayashi, Yoshiki, et al.
Publicado: (2022)

The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach
por: Ullah, Hammad, et al.
Publicado: (2022)

Conformational Dynamics, Ligand Binding and Effects of Mutations in NirE an S-Adenosyl-L-Methionine Dependent Methyltransferase
por: Singh, Warispreet, et al.
Publicado: (2016)

Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL-l-METHIONINE ACTIVATION
por: McCorvie, Thomas J., et al.
Publicado: (2014)

7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies
por: Bruender, Nathan A., et al.
Publicado: (2017)

S-Adenosyl-L-Methionine protects the probiotic yeast, Saccharomyces boulardii, from acid-induced cell death
por: Cascio, Vincent, et al.
Publicado: (2013)

(13)C-metabolic flux analysis of ethanol-assimilating Saccharomyces cerevisiae for S-adenosyl-l-methionine production
por: Hayakawa, Kenshi, et al.
Publicado: (2018)

The Atypical Cobalamin-Dependent S-Adenosyl-l-Methionine Nonradical Methylase TsrM and Its Radical Counterparts
por: Ulrich, Emily C., et al.
Publicado: (2022)

Biosynthesis of coelulatin for the methylation of anthraquinone featuring HemN-like radical S-adenosyl-L-methionine enzyme
por: Nie, Lishuang, et al.
Publicado: (2022)

Tyrosine, Cysteine, and S-Adenosyl Methionine Stimulate In Vitro [FeFe] Hydrogenase Activation
por: Kuchenreuther, Jon M., et al.
Publicado: (2009)

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites()
por: le Roux, Dina, et al.
Publicado: (2013)

Discovery and Characterization of BlsE, a Radical S-Adenosyl-L-methionine Decarboxylase Involved in the Blasticidin S Biosynthetic Pathway
por: Feng, Jun, et al.
Publicado: (2013)

A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
por: Jin, Wen-Bing, et al.
Publicado: (2018)

Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
por: Li, Fei, et al.
Publicado: (2019)

Effects of S-adenosyl-L-methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms
por: Mosca, Laura, et al.
Publicado: (2020)

Increasing glycolysis by deletion of kcs1 and arg82 improved S-adenosyl-l-methionine production in Saccharomyces cerevisiae
por: Chen, Hailong, et al.
Publicado: (2021)

Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins
por: Uegaki, Tesshin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jtgr3t9550379hroaq4tvpnles