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Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model

AIM: To compare the effect of University of Wisconsin (UW) solution with or without metformin, an AMP-activated protein kinase (AMPK) activator, for preserving standard and marginal liver grafts of young and aged rats ex vivo by hypothermic machine perfusion (HMP). METHODS: Eighteen young (4 mo old)...

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Detalles Bibliográficos
Autores principales: Chai, Yi-Chao, Dang, Guo-Xin, He, Hai-Qi, Shi, Jian-Hua, Zhang, Hong-Ke, Zhang, Rui-Tao, Wang, Bo, Hu, Liang-Shuo, Lv, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677206/
https://www.ncbi.nlm.nih.gov/pubmed/29142469
http://dx.doi.org/10.3748/wjg.v23.i40.7221