Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity

[Image: see text] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their antitubercular potential aga...

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Autores principales: dos Santos Fernandes, Guilherme Felipe, de Souza, Paula Carolina, Moreno-Viguri, Elsa, Santivañez-Veliz, Mery, Paucar, Rocio, Pérez-Silanes, Silvia, Chegaev, Konstantin, Guglielmo, Stefano, Lazzarato, Loretta, Fruttero, Roberta, Man Chin, Chung, da Silva, Patricia Bento, Chorilli, Marlus, Solcia, Mariana Cristina, Ribeiro, Camila Maríngolo, Silva, Caio Sander Paiva, Marino, Leonardo Biancolino, Bosquesi, Priscila Longhin, Hunt, Debbie M., de Carvalho, Luiz Pedro S., de Souza Costa, Carlos Alberto, Cho, Sang Hyun, Wang, Yuehong, Franzblau, Scott Gary, Pavan, Fernando Rogério, dos Santos, Jean Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677254/
https://www.ncbi.nlm.nih.gov/pubmed/28968083
http://dx.doi.org/10.1021/acs.jmedchem.7b01332

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