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Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina

BACKGROUND: Although the role of enteroviruses has been proved in heart diseases, extensive information is not available on the association between enteroviruses and unstable angina. In the present study, the authors compared the prevalence of enteroviruses in patients with and without unstable angi...

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Autores principales: Gholoobi, Aida, Meshkat, Zahra, Baghani, Akram, Alavi, Maryam Sadat, Mohammadpoor, Toktam, Momen-Heravi, Mastoureh, Mouhebati, Mohsen, Sepahi, Samaneh, Rostami, Sina, Meshkat, Mojtaba, Gholoobi, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677318/
https://www.ncbi.nlm.nih.gov/pubmed/29147125
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author Gholoobi, Aida
Meshkat, Zahra
Baghani, Akram
Alavi, Maryam Sadat
Mohammadpoor, Toktam
Momen-Heravi, Mastoureh
Mouhebati, Mohsen
Sepahi, Samaneh
Rostami, Sina
Meshkat, Mojtaba
Gholoobi, Arash
author_facet Gholoobi, Aida
Meshkat, Zahra
Baghani, Akram
Alavi, Maryam Sadat
Mohammadpoor, Toktam
Momen-Heravi, Mastoureh
Mouhebati, Mohsen
Sepahi, Samaneh
Rostami, Sina
Meshkat, Mojtaba
Gholoobi, Arash
author_sort Gholoobi, Aida
collection PubMed
description BACKGROUND: Although the role of enteroviruses has been proved in heart diseases, extensive information is not available on the association between enteroviruses and unstable angina. In the present study, the authors compared the prevalence of enteroviruses in patients with and without unstable angina. METHODS: Blood samples were taken from 51 patients with unstable angina and 55 patients without unstable angina or myocardial infarction that were admitted to Imam Reza and Ghaem hospitals (Mashhad, northeast of Iran). Reverse transcription polymerase chain reaction (RT-PCR) was performed using specific primers for the detection of the enteroviruses in blood samples of study subjects. RESULTS: Patients with and without unstable angina were similar in age with mean ± standard deviation of 62.6 ± 12.8 and 59.7 ± 12.7 years, respectively (P = 0.243) and there were no differences in gender in these two groups (P = 0.174). Prevalence of the enteroviruses in patients with unstable angina was higher only in 66-80 years age group compared to the control group (patients without unstable angina, P = 0.032). There was a higher prevalence of enterovirus RNA positivity in the blood samples of women with unstable angina (75.9%) than those without unstable angina (41.7%, P = 0.011), however, no significant difference was observed in men (P = 0.983). CONCLUSION: Our data showed that enteroviral RNA positivity was higher in patients with unstable angina compared to those without unstable angina. However, the differences between the two groups were not statistically significant.
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spelling pubmed-56773182017-11-16 Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina Gholoobi, Aida Meshkat, Zahra Baghani, Akram Alavi, Maryam Sadat Mohammadpoor, Toktam Momen-Heravi, Mastoureh Mouhebati, Mohsen Sepahi, Samaneh Rostami, Sina Meshkat, Mojtaba Gholoobi, Arash ARYA Atheroscler Original Article BACKGROUND: Although the role of enteroviruses has been proved in heart diseases, extensive information is not available on the association between enteroviruses and unstable angina. In the present study, the authors compared the prevalence of enteroviruses in patients with and without unstable angina. METHODS: Blood samples were taken from 51 patients with unstable angina and 55 patients without unstable angina or myocardial infarction that were admitted to Imam Reza and Ghaem hospitals (Mashhad, northeast of Iran). Reverse transcription polymerase chain reaction (RT-PCR) was performed using specific primers for the detection of the enteroviruses in blood samples of study subjects. RESULTS: Patients with and without unstable angina were similar in age with mean ± standard deviation of 62.6 ± 12.8 and 59.7 ± 12.7 years, respectively (P = 0.243) and there were no differences in gender in these two groups (P = 0.174). Prevalence of the enteroviruses in patients with unstable angina was higher only in 66-80 years age group compared to the control group (patients without unstable angina, P = 0.032). There was a higher prevalence of enterovirus RNA positivity in the blood samples of women with unstable angina (75.9%) than those without unstable angina (41.7%, P = 0.011), however, no significant difference was observed in men (P = 0.983). CONCLUSION: Our data showed that enteroviral RNA positivity was higher in patients with unstable angina compared to those without unstable angina. However, the differences between the two groups were not statistically significant. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2017-07 /pmc/articles/PMC5677318/ /pubmed/29147125 Text en © 2017 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Gholoobi, Aida
Meshkat, Zahra
Baghani, Akram
Alavi, Maryam Sadat
Mohammadpoor, Toktam
Momen-Heravi, Mastoureh
Mouhebati, Mohsen
Sepahi, Samaneh
Rostami, Sina
Meshkat, Mojtaba
Gholoobi, Arash
Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
title Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
title_full Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
title_fullStr Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
title_full_unstemmed Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
title_short Comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
title_sort comparison of the prevalence of enteroviruses in blood samples of patients with and without unstable angina
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677318/
https://www.ncbi.nlm.nih.gov/pubmed/29147125
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