The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells

N(6)-methyladenosine (m(6)A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether m(6)A controls differentiation of normal and/or malignant myeloid hematopoietic cells. Here we show that shRNA-media...

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Detalles Bibliográficos
Autores principales: Vu, Ly P., Pickering, Brian F., Cheng, Yuanming, Zaccara, Sara, Nguyen, Diu, Minuesa, Gerard, Chou, Timothy, Chow, Arthur, Saletore, Yogesh, MacKay, Matthew, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Klimek, Virginia M., Garrett-Bakelman, Francine E., Melnick, Ari, Carroll, Martin, Mason, Christopher E., Jaffrey, Samie R., Kharas, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677536/
https://www.ncbi.nlm.nih.gov/pubmed/28920958
http://dx.doi.org/10.1038/nm.4416

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