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Gut microbiota composition may relate to weight loss rate in obese pet dogs

Obese dogs seem to have a different gut microbiome (GM) composition compared to lean dogs, and in humans, GM composition may negatively impact the ability to lose weight in some individuals. The purpose of this study was to investigate the interaction between exercise, weight‐loss and the compositio...

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Autores principales: Kieler, Ida N., Shamzir Kamal, Shamrulazhar, Vitger, Anne D., Nielsen, Dennis S., Lauridsen, Charlotte, Bjornvad, Charlotte R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677773/
https://www.ncbi.nlm.nih.gov/pubmed/29152318
http://dx.doi.org/10.1002/vms3.80
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author Kieler, Ida N.
Shamzir Kamal, Shamrulazhar
Vitger, Anne D.
Nielsen, Dennis S.
Lauridsen, Charlotte
Bjornvad, Charlotte R.
author_facet Kieler, Ida N.
Shamzir Kamal, Shamrulazhar
Vitger, Anne D.
Nielsen, Dennis S.
Lauridsen, Charlotte
Bjornvad, Charlotte R.
author_sort Kieler, Ida N.
collection PubMed
description Obese dogs seem to have a different gut microbiome (GM) composition compared to lean dogs, and in humans, GM composition may negatively impact the ability to lose weight in some individuals. The purpose of this study was to investigate the interaction between exercise, weight‐loss and the composition of GM in dogs. Eighteen obese pet dogs were recruited for a 12‐week weight‐loss intervention. All dogs were fed restrictively with a commercial high‐protein/high‐fibre dry diet, and eight of these dogs were enrolled in an exercise program in addition to the diet intervention. Faecal samples were collected and the dogs were weighed at week 0, week 6 and week 12. GM composition was determined using MiSeq‐based tag‐encoded 16S rRNA gene high‐throughput amplicon sequencing, and concentrations of short chain fatty acids (SCFA) by gas‐liquid chromatography. Total weight loss, food allowance and GM were not changed by exercise inclusion. However, Megamonas abundance negatively correlated with weight loss rate and Ruminococcaceae relative abundance was lower at 12 weeks in dogs with a faster weight loss rate (≥1% per week) compared with slower weight loss rate (<1% per week) independent of exercise. Acetic and propionic acid concentrations decreased in the dogs with a faster weight loss rate. Members of Megamonas and Ruminococcaceae produce acetic and propionic acids and we therefore interpret that having a GM that favour SCFA production may negatively affect weight loss rate in dogs. Weight loss rate in dogs may be related to the composition of the GM and its production of metabolites.
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spelling pubmed-56777732017-11-17 Gut microbiota composition may relate to weight loss rate in obese pet dogs Kieler, Ida N. Shamzir Kamal, Shamrulazhar Vitger, Anne D. Nielsen, Dennis S. Lauridsen, Charlotte Bjornvad, Charlotte R. Vet Med Sci Original Articles Obese dogs seem to have a different gut microbiome (GM) composition compared to lean dogs, and in humans, GM composition may negatively impact the ability to lose weight in some individuals. The purpose of this study was to investigate the interaction between exercise, weight‐loss and the composition of GM in dogs. Eighteen obese pet dogs were recruited for a 12‐week weight‐loss intervention. All dogs were fed restrictively with a commercial high‐protein/high‐fibre dry diet, and eight of these dogs were enrolled in an exercise program in addition to the diet intervention. Faecal samples were collected and the dogs were weighed at week 0, week 6 and week 12. GM composition was determined using MiSeq‐based tag‐encoded 16S rRNA gene high‐throughput amplicon sequencing, and concentrations of short chain fatty acids (SCFA) by gas‐liquid chromatography. Total weight loss, food allowance and GM were not changed by exercise inclusion. However, Megamonas abundance negatively correlated with weight loss rate and Ruminococcaceae relative abundance was lower at 12 weeks in dogs with a faster weight loss rate (≥1% per week) compared with slower weight loss rate (<1% per week) independent of exercise. Acetic and propionic acid concentrations decreased in the dogs with a faster weight loss rate. Members of Megamonas and Ruminococcaceae produce acetic and propionic acids and we therefore interpret that having a GM that favour SCFA production may negatively affect weight loss rate in dogs. Weight loss rate in dogs may be related to the composition of the GM and its production of metabolites. John Wiley and Sons Inc. 2017-11-03 /pmc/articles/PMC5677773/ /pubmed/29152318 http://dx.doi.org/10.1002/vms3.80 Text en © 2017 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Kieler, Ida N.
Shamzir Kamal, Shamrulazhar
Vitger, Anne D.
Nielsen, Dennis S.
Lauridsen, Charlotte
Bjornvad, Charlotte R.
Gut microbiota composition may relate to weight loss rate in obese pet dogs
title Gut microbiota composition may relate to weight loss rate in obese pet dogs
title_full Gut microbiota composition may relate to weight loss rate in obese pet dogs
title_fullStr Gut microbiota composition may relate to weight loss rate in obese pet dogs
title_full_unstemmed Gut microbiota composition may relate to weight loss rate in obese pet dogs
title_short Gut microbiota composition may relate to weight loss rate in obese pet dogs
title_sort gut microbiota composition may relate to weight loss rate in obese pet dogs
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677773/
https://www.ncbi.nlm.nih.gov/pubmed/29152318
http://dx.doi.org/10.1002/vms3.80
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